223480-02-2Relevant academic research and scientific papers
Novel ester linked glycosyl amino acids: Convenient building blocks for the synthesis of glycopeptide libraries
Tennant-Eyles, Richard J.,Fairbanks, Antony J.
, p. 391 - 401 (1999)
The completely orthogonally protected aspartic acid derivative FmocAsp(OBn)O'Bu is readily synthesized on a large scale. Deprotection of the β-carboxylic acid allows coupling to various sugar derivatives via free hydroxyl groups to produce novel glycosyl amino acids. Subsequent deprotection of either the α-acid or nitrogen is achieved cleanly to allow elaboration into an oligopeptide, whilst selective deprotection of PMB protected sugar hydroxyls is also readily achievable. Such novel glycosyl amino acid building blocks may be useful for the combinatorial synthesis of novel glycopeptide libraries.
