2235-90-7 Usage
Originator
Monase,Upjohn,US,1961
Uses
α-Ethyltryptamine (E931900) is used as a stimulant and entactogen that have actions at multiple central nervous system (CNS) receptor sites.
Manufacturing Process
A mixture of 5 parts of 3-(2'-ethyl-2'-nitrovinyl)indole in 80 parts of ethanol
saturated with ammonia gas is shaken in an atmosphere of hydrogen at 100
atmospheres pressure and at 20°C in the presence of 1 part of a 5%palladium on carbon catalyst until the theoretical amount of hydrogen is
absorbed. The catalyst is removed by filtration. The ethanol and ammonia are
then removed from the filtrate by distillation under reduced pressure. The
residual oil is dissolved in 170 parts of dry ether, 50 parts of potassium
hydroxide pellets are added and the solution is kept at 18°C to 22°C for 2
hours. The mixture is filtered and hydrogen chloride is passed into the filtrate
to precipitate crude (α-ethyltryptamine hydrochloride. This is purified by
crystallization from methanol/ethyl acetate and it then has a MP of 221°C.
Therapeutic Function
Central stimulant
Check Digit Verification of cas no
The CAS Registry Mumber 2235-90-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,3 and 5 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 2235-90:
(6*2)+(5*2)+(4*3)+(3*5)+(2*9)+(1*0)=67
67 % 10 = 7
So 2235-90-7 is a valid CAS Registry Number.
InChI:InChI=1S/C12H16N2/c1-2-10(13)7-9-8-14-12-6-4-3-5-11(9)12/h3-6,8,10,14H,2,7,13H2,1H3
2235-90-7Relevant articles and documents
-
Snyder,Katz
, p. 3140 (1947)
-
Alpha-ethyltryptamines as dual dopamine-serotonin releasers
Blough, Bruce E.,Landavazo, Antonio,Partilla, John S.,Decker, Ann M.,Page, Kevin M.,Baumann, Michael H.,Rothman, Richard B.
, p. 4754 - 4758 (2015/01/09)
The dopamine (DA), serotonin (5-HT), and norepinephrine (NE) transporter releasing activity and serotonin-2A (5-HT2A) receptor agonist activity of a series of substituted tryptamines are reported. Three compounds, 7b, (+)-7d and 7f, were found to be potent dual DA/5-HT releasers and were >10-fold less potent as NE releasers. Additionally, these compounds had different activity profiles at the 5-HT2Areceptor. The unique combination of dual DA/5-HT releasing activity and 5-HT2Areceptor activity suggests that these compounds could represent a new class of neurotransmitter releasers with therapeutic potential.
Instantaneous SmI2/H2O/amine mediated reduction of nitroalkanes and α,β-unsaturated nitroalkenes
Ankner, Tobias,Hilmersson, G?ran
, p. 5707 - 5710 (2008/02/10)
A rapid method for efficient reduction of nitroalkanes and α,β-unsaturated nitroalkenes using SmI2/H2O/amine has been developed.
This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.