223511-25-9Relevant academic research and scientific papers
Enantioselective syntheses of spiroketals via a tandem reaction of Cu(I)-catalyzed cycloetherification and hydrogen-bond-induced [4 + 2] cyclization
Tian, Tian,Li, Liqi,Xue, Jijun,Zhang, Jie,Li, Ying
, p. 4189 - 4200 (2015)
A tandem reaction consisting of a copper(I)-catalyzed cycloetherification and a hydrogen-bond-induced inverse-electron-demand oxa-Diels-Alder cycloaddition was performed from chiral propargyl alcohol, generating several kinds of optically pure [5, 6] spir
Novel synthetic routes suitable for constructing benzopyrone combinatorial libraries
Bhat, Abhijit S.,Whetstone, Jennifer L.,Brueggemeier, Robert W.
, p. 2469 - 2472 (2007/10/03)
A series of O-(t-butylsilyloxy)benzoyl chlorides generated from the corresponding silyl esters were coupled with a range of terminal alkynes to afford the corresponding alkynyl ketones. The alkynyl ketones were converted to enaminoketones and then cyclized to yield the desired benzopyrone ring system. This synthetic protocol utilizes readily available starting materials, mild and high yielding reactions with good functional group tolerance, and is ideal for developing combinatorial libraries centered around the benzopyrone ring system.
