627-41-8

Usage

Uses

Used in Pharmaceutical Industry:
Methyl Propargyl Ether is used as a reactive intermediate for the synthesis of various pharmaceutical compounds. Its reactivity allows for the creation of a wide range of drug molecules, making it a valuable component in the development of new medications.
Used in Agrochemical Industry:
In the agrochemical sector, Methyl Propargyl Ether is employed as a reactive intermediate for the production of agrochemicals. Its ability to form a variety of compounds makes it useful in the synthesis of pesticides, herbicides, and other agricultural chemicals.
Used in Specialty Materials Industry:
Methyl Propargyl Ether is used as a reactive intermediate in the production of specialty materials. Its versatility in forming different compounds contributes to the development of unique materials with specific properties for various applications.

InChI:InChI=1/C4H6O/c1-3-4-5-2/h1H,4H2,2H3

Upstream product

• 67-56-1 methanol 
• 96-11-7 1,2,3-tribromopropane 
• 5836-66-8 1,2-dibromo-3-methoxypropane 
• 37675-34-6 1-bromo-3-methoxy-propene 
• 107-19-7 propargyl alcohol 
• 77-78-1 dimethyl sulfate 
• 22537-06-0 3,3-dimethoxyprop-1-yne 
• 56-23-5 tetrachloromethane 
• 108-88-3 toluene 
• 71-43-2 benzene 
• 64-17-5 ethanol 
• 74-88-4 methyl iodide 
• 106-96-7 propargyl bromide 
• 40365-61-5 2-(but-3-yn-1-yloxy)tetrahydropyran 

Downstream Products

• 24528-23-2 1-(Phenyl-ethyl-amino)-4-methoxy-butin-⁽²⁾ 
• 13168-99-5 methyl 4-methoxy-trans-crotonate 
• 112552-28-0 9-Hydroxy-10-phenylimino-9-<3-methoxy-propin-(1)-yl>-9,10-dihydro-anthracen 
• 101729-51-5 1-Hydroxy-4-phenylimino-2,6-dimethyl-1-<3-methoxy-propin-(1)-yl>-cyclohexadien-(2,5) 
• 13169-00-1 Methoxyallene 
• 84941-00-4 1,2,4-tris(methoxymethyl)-benzene 
• 66313-04-0 2-Methoxy-pentandien-3,4-carbonsaeure-ethylester 
• 127839-26-3 2-Methoxymethyl-cycloprop-2-enecarboxylic acid ethyl ester 
• 78961-60-1 1,4-Dimethoxy-4-methyl-pent-2-yne 
• 118891-04-6 methyl (E)-3-(methoxymethyl)hexa-2,5-dienoate 
• 118891-02-4 methyl (Z)-2-(methoxymethyl)hexa-2,5-dienoate 
• 118891-03-5 5-(methoxycarbonyl)-2-(methoxymethyl)cyclohex-2-enone 
• 118891-01-3 5-<(methoxycarbonyl)methyl>-2-(methoxymethyl)cyclopent-2-enone 
• 126741-68-2 1-<(1',1'-dimethylethyl)diphenylsilyl>-3-methoxyprop-1-yne 

Relevant academic research and scientific papers

The methoxyallene approach to oxacycles, part 2: Stereoselective synthesis of 2,3-disubstituted oxepanes

2,3-Disubstituted oxepanes 3 and 4 were stereoselectively synthesized from methoxyallene (1) and iodide 2. The trans stereochemistry of diol 3 was established by NMR studies of the bicyclic precursor 10, while the cis stereochemistry of 4 was secured by using the highly diastereoselective reducing agent L-Selectride. Georg Thieme Verlag Stuttgart.

Methoxyallene, a building block for the synthesis of seven-membered oxacycles

An efficient new approach for the synthesis of seven-membered oxacycles is described.

PYRIMIDINE-FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Disclosed in the present disclosure are a pyrimidine-fused cyclic compound or a pharmaceutically acceptable salt, hydrate, prodrug, stereoisomer, solvate or isotope labeled compound thereof. Also provided in the present disclosure are a preparation method for the compound, a composition comprising the compound and a use of the compound for the preparation of a medicament for the prevention and/or treatment of a disease or condition associated with abnormal SHP2 activity.

Design of a mesoscale continuous-flow route toward lithiated methoxyallene

The unique nucleophilic properties of lithiated methoxyallene allow for C C bond formation with a wide variety of electro-philes, thus introducing an allenic group for further functionali-zation. This approach has yielded a tremendously broad range of (hetero)cyclic scaffolds, including precursors to active pharmaceutical ingredients. To date, however, its valorization at scale is hampered by the batch synthesis procedure, which suf- fers from serious safety issues. Hence, the attractive heat-and mass-transfer properties of flow technology were exploited to establish a mesoscale continuous-flow route toward lithiated methoxyallene. An excellent conversion of 94 % was obtained, corresponding to a methoxyallene throughput of 8.2 g h1. The process is characterized by short reaction times, mild reaction conditions and a stoichiometric use of reagents.

Synthesis of polyfunctional triethoxysilanes by 'click silylation'

The copper-catalyzed 'click silylation' has been exploited for the chemical modification of γ-azidopropyltriethoxysilane (AzPTES) with a wide range of terminal alkynes (1a-1v) in a one-pot operation. The novel 1,2,3-triazole-triethoxysilane derivatives (2a-2v) were synthesized by this procedure and comprehensively characterized by IR spectra, 1H and 13C NMR, and HRMS studies.

NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS

The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.

Synthesis of polyfunctional triethoxysilanes by 'click silylation'

The copper-catalyzed 'click silylation' has been exploited for the chemical modification of γ-azidopropyltriethoxysilane (AzPTES) with a wide range of terminal alkynes (1a-1v) in a one-pot operation. The novel 1,2,3-triazole-triethoxysilane derivatives (2a-2v) were synthesized by this procedure and comprehensively characterized by IR spectra, 1H and 13C NMR, and HRMS studies.

COMPOUNDS AND ANTI-TUMOR NQO1 SUBSTRATES

Compounds of Formula (I) can be selectively lethal toward a variety of different cancer cell types. The compounds are useful for the management, treatment, control, or adjunct treatment of diseases, where the selective lethality is beneficial in chemotherapeutic therapy.

Pendant triazole ring assisted mesogen containing side chain liquid crystalline polymethacrylates: Synthesis and characterization

Two series of click chemistry assisted alkoxymethyl-1H-[1,2,3]-triazol-1-yl containing sidechain liquid-crystalline polymethacrylates were synthesized by free radical polymerization technique. Mesogen was linked to backbone through various spacer units. Monomers and polymers were characterized by FT-IR, 1H and 13C-NMR spectral techniques. Thermal stability of polymers was confirmed by thermogravimetric analysis. Mesomorphic property and phase transition temperature of polymers were analysed by differential scanning calorimetry and polarized optical microscopy. Phase transition temperature and mesomorphic property of polymers with respect to insertion of polar alkoxy group on terminal triazole ring and spacer length between backbone and mesogen were investigated. Polymers exhibited grainy like textures under polarized optical microscopy. Spacer length between mesogen and backbone alters phase transition temperature of the polymers. Indian Academy of Sciences.

Direct, catalytic synthesis of carbapenams via cycloaddition/rearrangement cascade reaction: Unexpected acetylenes' structure effect

Reactions of acetylenes derived from glyceraldehyde and propargyl aldehyde show remarkable reactivity in Kinugasa cycloaddition/rearrangement cascade process catalyzed by Cu(I) ion. Reactions proceed by formation of a rigid dinuclear copper(I) complex in which each copper ion is coordinated to one or both oxygen atoms in the acetylene molecule and to both triple bonds. It has been demonstrated that one oxygen atom can be replaced by the phenyl ring, which is able to coordinate the copper ion by the aromatic sextet. Kinugasa reactions that proceed in a high yield can also be performed in the presence of a catalytic amount of the copper salt to provide products in an acceptable yield without a decrease of diastereoselectivity.