223564-75-8Relevant academic research and scientific papers
C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4)inhibitors, compound profiling in cell-based target engagement assays
Le Bihan, Yann-Va?,Lanigan, Rachel M.,Atrash, Butrus,McLaughlin, Mark G.,Velupillai, Srikannathasan,Malcolm, Andrew G.,England, Katherine S.,Ruda, Gian Filippo,Mok, N. Yi,Tumber, Anthony,Tomlin, Kathy,Saville, Harry,Shehu, Erald,McAndrew, Craig,Carmichael, LeAnne,Bennett, James M.,Jeganathan, Fiona,Eve, Paul,Donovan, Adam,Hayes, Angela,Wood, Francesca,Raynaud, Florence I.,Fedorov, Oleg,Brennan, Paul E.,Burke, Rosemary,van Montfort, Rob L.M.,Rossanese, Olivia W.,Blagg, Julian,Bavetsias, Vassilios
supporting information, p. 316 - 337 (2019/06/05)
Residues in the histone substrate binding sites that differ between the KDM4 and KDM5 subfamilies were identified. Subsequently, a C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-one series was designed to rationally exploit these residue differences between
NEW AZIRIDINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS ACETYL-COA CARBOXYLASE INHIBITORS
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Page/Page column 82; 83, (2013/07/05)
The invention relates to new azetidine derivatives of the formula (I) wherein Ar1, Ar2, X, R, T and L are as defined in the description, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
AZETIDINE DERIVATIVES
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Paragraph 0495; 0496; 0497; 0498; 0499; 0500, (2013/06/28)
Azetidine derivatives of which the following is exemplary and their use in the treatment of obesity, diabetes or dyslipidemia.
Polymer electroluminescent device
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, (2008/06/13)
A polymer electroluminescent device (1) comprises an electroluminescent layer (7) of a poly(1,4-phenylenevinylene) having aryl-1,4-phenylene units, where the aryl group is a phenyl, naphthyl or biphenylyl group. Using such a poly(1,4-phenylenevinylene) has the effect that the light emitted by the polymer electroluminescent device has no or at least a reduced tendency to change color when driven the device is and/or kept at an elevated ambient temperature of, for example, 70 °C. The poly(1,4-phenylenevinylene)s having aryl-1,4-phenylene units are prepared using aryl-bishalomethylbenzenes as an intermediate compound.
