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223575-93-7

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223575-93-7 Usage

Description

3'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-2-CARBALDEHYDE is a chemical compound that shares structural characteristics with biphenyl compounds, known for its two phenyl groups. The presence of the trifluoromethyl group renders the compound more lipophilic and increases its chemical stability. Its aldehyde group can react with various nucleophiles. It is particularly relevant in the pharmaceutical and chemical industry where it is often used as an intermediate product for the synthesis of more complex substances. It often serves as a building block in the creation of numerous fluorinated compounds which are widely known for their efficacy in various fields from pharmaceuticals to agrochemicals. However, information regarding its safety, toxicity or environmental impact is not widely available as of now.

Uses

Used in Pharmaceutical Industry:
3'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-2-CARBALDEHYDE is used as an intermediate product for the synthesis of more complex substances, particularly in the creation of fluorinated compounds. These compounds are known for their efficacy in various pharmaceutical applications.
Used in Chemical Industry:
3'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-2-CARBALDEHYDE is used as a building block in the creation of numerous fluorinated compounds. These compounds are widely used in various chemical applications, including the synthesis of agrochemicals and other complex substances.

Check Digit Verification of cas no

The CAS Registry Mumber 223575-93-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,3,5,7 and 5 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 223575-93:
(8*2)+(7*2)+(6*3)+(5*5)+(4*7)+(3*5)+(2*9)+(1*3)=137
137 % 10 = 7
So 223575-93-7 is a valid CAS Registry Number.

223575-93-7 Well-known Company Product Price

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  • Aldrich

  • (791202)  3′-(Trifluoromethyl)-1,1′-biphenyl-2-carboxaldehyde  96%

  • 223575-93-7

  • 791202-1G

  • 1,240.20CNY

  • Detail

223575-93-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[3-(trifluoromethyl)phenyl]benzaldehyde

1.2 Other means of identification

Product number -
Other names 3'-(trifluoromethyl)[1,1'-biphenyl]-2-carbaldehyde

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:223575-93-7 SDS

223575-93-7Downstream Products

223575-93-7Relevant articles and documents

Regio- and Chemoselective Kumada-Tamao-Corriu Reaction of Aryl Alkyl Ethers Catalyzed by Chromium under Mild Conditions

Cong, Xuefeng,Tang, Huarong,Zeng, Xiaoming

supporting information, p. 14367 - 14372 (2015/12/01)

Acting as an environmentally benign synthetic tool, the cross-coupling reactions with aryl ethers via C-O bond activation have attracted broad interest. However, the functionalizations of C-O bonds are mainly limited to nickel catalysis, and selectivity has long been a prominent challenge when several C-O bonds are present in the one molecule. We report here the first chromium-catalyzed selective cross-coupling reactions of aryl ethers with Grignard reagents by the cleavage of C-O(alkyl) bonds. Diverse transformations were achieved using simple, inexpensive chromium(II) precatalyst combining imino auxiliary at room temperature. It offers a new avenue for buildup functionalized aromatic aldehydes with high efficiency and selectivity.

Catalytic oxidative cyclization of 2′-arylbenzaldehyde oxime ethers under photoinduced electron transfer conditions

Hofstra, Julie L.,Grassbaugh, Brittany R.,Tran, Quan M.,Armada, Nicholas R.,De Lijser, H. J. Peter

, p. 256 - 265 (2016/09/09)

A series of 2′-arylbenzaldehyde oxime ethers were synthesized and shown to generate the corresponding phenanthridines upon irradiation in the presence of 9,10-dicyanoanthracene in acetonitrile. Mechanistic studies suggest that the oxidative cyclization reaction sequence is initiated by an electron transfer step followed by nucleophilic attack of the aryl ring onto the nitrogen of the oxime ether. A concave downward Hammett plot is presumably the result of a change in charge distribution in the radical cation species with strongly electron-donating substituents that yields a less electrophilic nitrogen atom and a decreased amount of cyclized product. The reaction is selective (no nitrile byproduct is formed unlike other photochemical reactions involving aldoxime ethers) as well as regiospecific when using 2′-aryl groups with metasubstituents, making this reaction a useful alternative for preparing substituted phenanthridines.

First and mild synthesis of fluorene-9-malonic acid and some substituted derivatives via the intramolecular hydroarylation of 2-phenylbenzylidenemalonic acids

Chosson, Elizabeth,Rochais, Christophe,Legay, Remi,Santos, Jana Sopkova De Oliveira,Rault, Sylvain,Dallemagne, Patrick

experimental part, p. 2548 - 2554 (2011/04/25)

Hitherto unknown fluorene-9-malonic acid and some substituted derivatives were easily synthesized in very mild conditions through the intramolecular hydroarylation of 2-phenylbenzylidenemalonic acids issued from the corresponding biphenylcarboxaldehydes.

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