223576-64-5

Basic information

• Product Name: Boronic acid, B-(5-chloro-2-benzofuranyl)-
• Synonyms: Boronic acid, B-(5-chloro-2-benzofuranyl)-;(5-Chlorobenzofuran-2-yl)boronic acid;5-chlorobenzofuran-2-boronic acid
• CAS NO: 223576-64-5
• Molecular Formula: C₈H₆BClO₃
• Molecular Weight: 196.39544
• EINECS: -0
• Product Categories: Organic boronic acid
• Mol File: 223576-64-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Boronic acid, B-(5-chloro-2-benzofuranyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Boronic acid, B-(5-chloro-2-benzofuranyl)-(223576-64-5)
• EPA Substance Registry System: Boronic acid, B-(5-chloro-2-benzofuranyl)-(223576-64-5)

Safety Data

• Hazardous Substances Data: 223576-64-5(Hazardous Substances Data)

Usage

Uses

5-Chlorobenzofuran-2-boronic Acid acts as a reagent in the synthesis of (ary)benzofuran containing natural products. Also acts as a reagent for the preparation of quinoxaline compounds for the inhibition of PASK useful in treating diseases.

Upstream product

• 3261-05-0 5-chlorobenzofuran-3(2H)-one 

Downstream Products

• 24472-98-8 5-Chloro-2-(4-methoxy-phenyl)-benzofuran 
• 67024-72-0 5-chloro-2-(4-chlorophenyl)benzo[b]furan 
• 227802-79-1 5-chloro-2-m-tolyl-benzo[b]furan 

Relevant articles and documents

Total synthesis of the 2-arylbenzo[b]furan-containing natural products from Artocarpus

In this study, 2-arylbenzo[b]furan-containing derivatives moracin C (1) and moracin M (4), the natural products from Artocarpus, have been synthesized in highest overall yield to date (1, 7 steps with an overall yield of 41.9%; 4, 6 steps with an overall yield of 56.3%), and we also report the first total synthesis of artoindonesianin B-1 (2), another member of this family, in the same route (8 steps with an overall yield of 11.3%). This discovery provides a concise route for preparing enough amounts of 1, 2, and 4 as well as 2-arylbenzo[b]furan-containing natural product-like analogs (71-74) to explore the biological potential.