Boronic acid, B-(5-chloro-2-benzofuranyl)-

Base Information

• Chemical Name: Boronic acid, B-(5-chloro-2-benzofuranyl)-
• CAS No.: 223576-64-5
• Molecular Formula: C8H6BClO3
• Molecular Weight: 196.398
• Mol file: 223576-64-5.mol

Synonyms:Boronic acid, B-(5-chloro-2-benzofuranyl)-;(5-Chlorobenzofuran-2-yl)boronic acid;5-chlorobenzofuran-2-boronic acid

Chemical Property of Boronic acid, B-(5-chloro-2-benzofuranyl)-

Chemical Property:

• PSA: 53.60000
• LogP: 0.76600
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

5-Chlorobenzofuran-2-boronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Chlorobenzofuran-2-boronic Acid acts as a reagent in the synthesis of (ary)benzofuran containing natural products. Also acts as a reagent for the preparation of quinoxaline compounds for the inhibition of PASK useful in treating diseases.

Technology Process of Boronic acid, B-(5-chloro-2-benzofuranyl)-

There total 1 articles about Boronic acid, B-(5-chloro-2-benzofuranyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chlorobenzofuran-3(2H)-one (3261-05-0) → (5-chlorobenzofuran-2-yl)boronic acid (223576-64-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / methanol / 4 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: -78 - 20 °C

2.3: 20 °C / pH 5

With sodium tetrahydroborate; n-butyllithium; In tetrahydrofuran; methanol; hexane;

DOI:10.1016/j.tetlet.2015.05.093

Reference yield: 76.0%

(5-chlorobenzofuran-2-yl)boronic acid (223576-64-5) + 1-Chloro-4-iodobenzene (637-87-6) → 5-chloro-2-(4-chlorophenyl)benzo[b]furan (67024-72-0)

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾;

Reference yield: 66.0%

(5-chlorobenzofuran-2-yl)boronic acid (223576-64-5) + 3-Iodotoluene (625-95-6) → 5-chloro-2-m-tolyl-benzo[b]furan (227802-79-1)

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾;

upstream raw materials:

5-chlorobenzofuran-3(2H)-one

Downstream raw materials:

5-Chloro-2-(4-methoxy-phenyl)-benzofuran

5-chloro-2-m-tolyl-benzo[b]furan

5-chloro-2-(4-chlorophenyl)benzo[b]furan

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 223576-64-5 Boronic acid, B-(5-chloro-2-benzofuranyl)-

Send

Send

Metric Ton KG G Pound L ML

Send

Send