22360-47-0Relevant academic research and scientific papers
Water-Mediated ortho-Carboxymethylation of Aryl Ketones under Ir(III)-Catalytic Conditions: Step Economy Total Synthesis of Cytosporones A-C
Patel, Pitambar
, p. 4852 - 4862 (2022/04/07)
An expeditious Ir(III)-catalyzed carboxymethylation of aryl ketone with diazotized Meldrum's acid has been developed in aqueous medium. Flavanone and chromanone were also found to be facile substrates with the developed catalytic system. Mechanistic studies revealed the active catalytic species and the role of water in the reaction process as hydroxy and proton sources. Employing the developed method, total synthesis of cytosporone A was achieved in two steps and that of cytosporones B-C was achieved in three steps starting from resorcinol.
Synthesis of Isoindoles from Intramolecular Condensation of Benzyl Azides with α-Aryldiazoesters
Zhu, Jing,Li, Rui,Su, Yan,Gu, Peiming
, p. 5813 - 5820 (2019/04/16)
Rh-catalyzed intramolecular condensation of the benzyl azides with α-aryldiazoesters was explored. The reaction proceeded through the nucleophilic attack of the organic azide onto a rhodium carbenoid, while releasing nitrogen gas, affording the α-imino es
Visible-Light-Induced C-O Bond Formation for the Construction of Five- and Six-Membered Cyclic Ethers and Lactones
Im, Honggu,Kang, Dahye,Choi, Soyeon,Shin, Sanghoon,Hong, Sungwoo
supporting information, p. 7437 - 7441 (2018/11/27)
Visible-light-induced intramolecular C-O bond formation was developed using 2,4,6-triphenylpyrylium tetrafluoroborate (TPT), which allows the regiocontrolled construction of cyclic ethers and lactones. The reaction is likely to proceed through the single-electron oxidation of the phenyl group, followed by the formation of a benzylic radical, thus preventing a competing 1,5-hydrogen abstraction pathway. Detailed mechanistic studies suggest that molecular oxygen is used to trap the radical intermediate to form benzyl alcohol, which undergoes cyclization. This new approach serves as a powerful platform by providing efficient access to valuable five- and six-membered cyclic ethers and lactones with a unified protocol.
A new synthesis of 3-isochromanone derivatives based on the reaction of o-acylbenzyllithiums with ethyl chloroformate
Kobayashi,Mannami,Kawakita,Tokimatsu,Konishi
, p. 582 - 585 (2007/10/02)
A new method for the preparation of 3-isochromanone derivatives is reported. The method consists of the ethoxycarbonylation of o-acylbenzyllithiums with ethyl chloroformate and the subsequent NaBH4 reduction of the resulting o-acylphenylacetic
Synthesis and Structure-Activity Relationships of 1-Substituted-aminomethyl-3-phenyl/methyl-1,3-dihydroisobenzofurans and 4-Substituted-amino-1-phenyl/methyl-isochromans - A New Class of Antihistaminics
Ram, Siya,Saxena, Anil K.,Jain, Padam C.,Patnaik, G. K.
, p. 1261 - 1267 (2007/10/02)
The title compounds have been synthesized from the common intermediates 1-phenyl/methyl-4-bromo-3-isochromanones (10/11) which have been prepared from 2-benzoyl/acetyl-phenylacetic acids (6/7) by NaBH4 reduction followed by bromination of 1-phenyl/methyl-
2-(Arylmethyl)arylacetic Acids as Potential Antiinflammatory Agents
Brancaccio, Giovanni,Larizza, Angelo,Lettieri, Guglielmo,Monforte, Pietro
, p. 998 - 1000 (2007/10/02)
The title compounds 2 have been synthesized and tested for antiinflammatory activity.The synthetic method, consisting of the chemical sequence 3-aryl-1H-indenes (4) 2-(aroyl)arylacetic acids (5) 2, appears to be of value because of its simplicity
