2236129-81-8

Basic information

• Product Name: trifluoroacetaldehyde N-triftosylhydrazone
• CAS NO: 2236129-81-8
• Molecular Weight: 320.215
• Mol File: 2236129-81-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: trifluoroacetaldehyde N-triftosylhydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: trifluoroacetaldehyde N-triftosylhydrazone(2236129-81-8)
• EPA Substance Registry System: trifluoroacetaldehyde N-triftosylhydrazone(2236129-81-8)

Safety Data

• Hazardous Substances Data: 2236129-81-8(Hazardous Substances Data)

Upstream product

• 75-90-1 2,2,2-Trifluoroacetaldehyde 
• 890522-56-2 o-trifluoromethylbenzenesulfonyl hydrazide 
• 421-53-4 2,2,2-trifluoro-1,1-ethanediol 

Downstream Products

• 6833-82-5 3-trifluoromethyl-1H-pyrazole-5-carboxylic acid methyl ester 
• 26974-16-3 5-(thiophen-2-yl)-3-(trifluoromethyl)-1H-pyrazole 
• 129286-67-5 1-(trifluoromethyl)-3-butenyl phenylsulfide 

Relevant articles and documents

Metal-free [2 + 1 + 3] Cycloaddition of Trifluoroacetaldehyde N-Sulfonylhydrazones with Hexahydro-1,3,5-triazines Leading to Trifluoromethylated 2,3,4,5-Tetrahydro-1,2,4-triazines

A transition-metal-free [2 + 1 + 3] cycloaddition of trifluoroacetaldehyde N-sulfonylhydrazone and hexahydro-1,3,5-triazine was described. This operationally simple protocol provides a general synthesis of diverse trifluoromethylated 2,3,4,5-tetrahydro-1,2,4-triazines in 81-97% yield with a broad substrate scope, including aryl, benzyl, and alkyl hexahydro-1,3,5-triazine.

Coupling of Trifluoroacetaldehyde N-Triftosylhydrazone with Organoboronic Acids for the Synthesis of gem-Difluoroalkenes

The synthesis of alkyl gem-difluoroalkenes remains a difficult task in organic synthesis. Here, we report a general and efficient approach for tackling this problem by gem-difluoroolefination of trifluoroacetaldehyde N-triftosylhydrazone with organoboronic acids. This protocol is operationally simple, free of transition metals, and suitable for a broad range of organoboronic acids. Moreover, the utility of the products was demonstrated by further conversion of the gem-difluorovinyl group.