421-53-4Relevant academic research and scientific papers
Catalytic vapor-phase oxidation of 2,2,2-trifluoroethanol
Mimura, Hideyuki,Watanabe, Akio,Kawada, Kosuke
, p. 519 - 523 (2006)
The synthesis of trifluoroacetaldehyde by vapor-phase oxidation of 2,2,2-trifluoroethanol using supported vanadium catalysts was studied. Significant differences were observed in the reaction outcomes resulting from different types of catalysts. The ZrO2- and Al2O3-supported catalyst demonstrated both high catalytic activity and selectivity. The addition of co-catalysts such as MoO3 or SnO2 improved catalytic performance (Selectivity: up to 91%; S.T.Y.: >200 g L-1 h-1). The experimental results on catalyst lifetime showed a marked decrease in the activity of the Al2O3-supported catalyst within tens of hours, while the ZrO2-supported catalyst showed little, if any, performance alterations for 2000 h.
A simple and practical synthesis of α-trifluoromethylated alcohols in water
Loh, Teck-Peng,Li, Xu-Ran
, p. 5611 - 5622 (1999)
A simple and practical preparation of α-trifluoromethylated alcohols in water via indium-mediated allylation reaction and tin-mediated indium trichloride-promoted allylation reaction of trifluoroacetaldehyde hydrate and its ethyl hemiacetal is described in this paper.
Direct aldol reaction of trifluoroacetaldehyde ethyl hemiacetal with ketones by use of the combination of amines and acids
Funabiki, Kazumasa,Nagaya, Hideyuki,Ishihara, Mika,Matsui, Masaki
, p. 5049 - 5053 (2006)
Trifluoroacetaldehyde ethyl hemiacetal reacts with unmodified ketones in the presence of 30-50 each mol % of amines and acids at ambient temperature, affording the corresponding β-hydroxy-β-trifluoromethylated ketones in good yields with good to excellent diastereoselectivities.
Ru-Catalyzed Deoxygenative Regioselective C8-H Arylation of Quinoline N-Oxides
Kim, Jinwoo,Kim, Suhyeon,Kim, Dongwook,Chang, Sukbok
supporting information, p. 13150 - 13158 (2019/08/22)
Regioselective C-H functionalization on quinolines is of high interest to lead to value-added products. Herein, we describe the development of Ru-catalyzed deoxygenative regioselective C8 arylation of quinoline N-oxides with arylboronic esters. Mechanistic studies revealed that it proceeds in a tandem process of arylation and then deoxygenation, wherein both steps were found to be catalytic with the ruthenium species.
1,2-Bis(trifluoromethyl)ethene-1,2-dicarbonitrile: (2+2) cycloadditions with vinyl ethers
Urrutia-Desmaison, Gonzalo,Huisgen, Rolf,Noeth, Heinrich
experimental part, p. 1 - 16 (2012/03/07)
The title compound (short version: BTE) occurs in (E)- and (Z)-isomers (both with b.p. of ca. 100°) which equilibrate with nucleophilic catalysts. Both undergo (2+2) cycloadditions with methyl vinyl ether at 25°. Three stereogenic centers in the cyclobutanes led to four rac-diastereoisomers, which were obtained in pure and crystalline state. The structures were elucidated by 19F-NMR spectroscopy and confirmed by two X-ray analyses. The cycloadditions were not stereospecific: e.g., (E)-BTE furnished 73% trans-adducts (with respect to the CF3 groups) and 27% cis-adducts. The loss of stereochemical integrity occurs in the intermediate gauche-zwitterions which can cyclize or rotate, but not dissociate. Under extreme conditions (2M LiClO4 in Et2O, 70°, 3months), the thermodynamic equilibrium of the four cyclobutanes was achieved. Considerations of Coulombic attraction and conformational strain in the zwitterionic intermediates allow us to rationalize the observed proportions of diastereoisomeric cyclobutanes. Ethyl vinyl ether and butyl vinyl ether furnished cyclobutanes in similar diastereoisomer ratios. Copyright
Tetrahydropyridinyl and Dihydropyrrolyl Compounds and the Use Thereof
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Page/Page column 37, (2011/06/24)
The invention relates to tetrahydropyridinyl and dihydropyrrolyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein X, Y, Z, R1, R2, m, and n are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
Magnesium metal-mediated reductive trifluoromethylation of aldehydes with phenyl trifluoromethyl sulfone
Zhao, Yanchuan,Zhu, Jieming,Ni, Chuanfa,Hu, Jinbo
scheme or table, p. 1899 - 1904 (2010/08/19)
An unprecedented reductive nucleophilic trifluoromethylation of aldehydes by using phenyl trifluoromethyl sulfone is reported. Mercury(II) chloride efficiently activates magnesium metal to induce the desulfonylative trifluoromethylation process. The new r
Process of use in perfluoroalkyation and reactant for making use of this process
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Example 5, (2008/06/13)
The subject-matter of the present invention is a process of use in perfluoroalkylation and a reactant for making use of this process. This process is defined in that it comprises a stage in which a material of formula RfH and a base (or a species capable of generating a base) are brought into contact, in a polar and anhydrous medium, with a substrate carrying at least one electrophilic functional group. Application to organic synthesis.
Fluoroform: An efficient precursor for the trifluoromethylation of aldehydes
Folléas, Beno?t,Marek, Ilan,Normant, Jean-F.,Saint-Jalmes, Laurent
, p. 275 - 283 (2007/10/03)
Fluoroform is shown to be an efficient trifluoromethylating agent when deprotonated using standard reagents in DMF. The important role of DMF as a solvent but also as a reactant was demonstrated.
Effective nucleophilic trifluoromethylation with fluoroform and common base
Russell, Jamie,Roques, Nicolas
, p. 13771 - 13782 (2007/10/03)
Common bases (alcoholate, dimsyl anion or amide) are able to deprotonate trifluoromethane to form a trifluoromethyl anion equivalent. In this reaction DMF plays a crucial role of stabilisation Trifluoromethyl aryl alcohols, ketones or sulfides can be obtained in good yields with the new reagent CF3H/Base/DMF.
