223649-64-7Relevant academic research and scientific papers
PBN (phenyl-N-tert-butylnitrone)-derivatives are effective in slowing the visual cycle and rhodopsin regeneration and in protecting the retina from light-induced damage
Stiles, Megan,Moiseyev, Gennadiy P.,Budda, Madeline L.,Linens, Annette,Brush, Richard S.,Qi, Hui,White, Gary L.,Wolf, Roman F.,Ma, Jian-Xing,Floyd, Robert,Anderson, Robert E.,Mandal, Nawajes A.
, (2015)
A2E and related toxic molecules are part of lipofuscin found in the retinal pigment epithelial (RPE) cells in eyes affected by Stargardt's disease, age-related macular degeneration (AMD), and other retinal degenerations. A novel therapeutic approach for t
COMPOSITIONS AND METHODS OF INHIBITING RETINAL DEGENERATION
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Paragraph 0162; 0178; 0179; 0180, (2013/09/12)
Nitrone-based compositions are disclosed that may be utilized for the prevention and treatment of a variety of ophthalmic diseases or conditions where RPE65 protein isomerohydrolase is implicated. Methods of production and use of said nitrone-based compos
α-aryl-N-alkylnitrones and pharmaceutical compositions containing the same
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, (2008/06/13)
Disclosed are novel α-aryl-N-alkylnitrone compounds and pharmaceutical compositions containing such compounds. The disclosed compositions are useful as therapeutics for preventing and/or treating neurodegenerative, autoimmune and inflammatory conditions in mammals and as analytical reagents for detecting free radicals.
