223671-53-2

Usage

Uses

Used in Organic Synthesis:
1-Chloroisoquinoline-7-carbaldehyde is used as a reagent in organic synthesis for its ability to facilitate the creation of a range of chemical compounds. Its unique structure allows it to participate in various chemical reactions, making it a valuable component in the synthesis process.
Used in Pharmaceutical Industry:
1-Chloroisoquinoline-7-carbaldehyde is used as an intermediate in the manufacture of pharmaceuticals. Its potential applications include the development of antipsychotic and antifungal medications, where it contributes to the formation of active pharmaceutical ingredients that address specific health conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 1-Chloroisoquinoline-7-carbaldehyde is utilized as an intermediate for the production of agrochemicals. It plays a role in the development of substances that can protect crops from pests and diseases, thereby ensuring agricultural productivity.
Used in the Synthesis of Biologically Active Molecules:
1-Chloroisoquinoline-7-carbaldehyde is also used as a building block in the synthesis of a variety of biologically active molecules. Its structural properties make it suitable for the creation of compounds that can interact with biological systems, potentially leading to new therapeutic agents or other bioactive substances.

InChI:InChI=1/C10H6ClNO/c11-10-9-5-7(6-13)1-2-8(9)3-4-12-10/h1-6H

Upstream product

• 107-31-3 Methyl formate 
• 215453-51-3 7-bromo-1-chloroisoquinoline 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 223671-64-5 1-Chloro-7-hydroxymethylisoquinoline 

Relevant academic research and scientific papers

Iron-Catalyzed Synthesis of C2 Aryl- and N-Heteroaryl-Substituted Tetrahydropyrans

An iron-catalyzed cyclization of hydroxy allylic derivatives into tetrahydropyrans possessing an N-heteroaryl at C2 is disclosed. The reaction proceeds with good yield and in high diastereoselectivity in favor of the more stable isomer. The diastereoselectivity results from an iron-induced reopening of the tetrahydropyrans, allowing a thermodynamic equilibration. The method allows access to a variety of 2,6-disubstituted as well as 2,4,6-trisubstituted tetrahydropyrans that could be considered as attractive scaffolds for the pharmaceutical industry.

Lewis basicity modulation of N-heterocycles: A key for successful cross-metathesis

Cross-metathesis involving N-heteroaromatic olefinic derivatives is disclosed. The introduction of an appropriate substituent on the heteroaromatic ring decreases the Lewis basicity of the nitrogen atom, thus preventing the deactivation of the ruthenium-centered catalyst. The reaction is quite general in terms of both N-heterocycles and olefinic partners.

Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-Isoquinolinylguanidines

A series of 1-isoquinolinylguanidines are shown to be potent inhibitors of uPA with selectivity over tPA and plasmin. Potency is enhanced by the presence of a 4-halo and a 7-aryl substituent, particularly when substituted by a 3-carboxylic acid group. Compound 13j (UK-356,202) combines excellent potency and selectivity, and has been selected as a candidate for clinical evaluation.

Isoquinolines as urokinase inhibitors

Compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein one of R1 and R2 is H and the other is N=C(NH2)2 or NHC(=NH)NH2, and the other substituents are as defined herein, are urokinase (uPA) inhibitors.