223674-01-9Relevant academic research and scientific papers
Silyl modification of biologically active compounds. 5. Hydrolytic stability and biological activity of the trialkylsilyl derivatives of some heterocyclic bases
Lukevits,Segal,Birgele,Zablotskaya
, p. 1076 - 1080 (1998)
The kinetics of the desilylation of the triorganosilyl derivatives of some biologically active heterocyclic bases and uridine were investigated by 1H NMR spectroscopy. A correlation was established between the relative rates of desilylation and the steric environment of the silicon atom. In trials on locomotor activity and muscular tone, the effect on memory processes, and the Porsolt test it was found that tris(tert-butylmethylsilyl)barbituric acid has higher sedative activity than barbituric acid. In contrast to uridine, 5′-O-tert-butyldimethylsilyluridine exhibits antitumor activity, suppressing the development of fibrosarcoma in human lungs (HT-1080) and fibroblasts in mice. 1999 Kluwer Academic/Plenum Publishers.
SUBSTANCES FOR DYEING KERATINOUS FIBERS
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, (2010/03/04)
Disclosed are substances which contain unsaturated, non-aromatic dialdehydes of formula (Ia) and/or the tautomer (Ib) thereof, wherein R1, R2, and R3 are defined as indicated in claim 1, along with at least one CH-acidic compound of formulas (II) and/or (III), wherein R6, R7, R8, R9, R10, Y, X?, Het, and X1 are defined as indicated in claim 1, in a cosmetic carrier. Said substances color keratinous fibers, especially human hair, in an intensive, colorfast, natural brown shade.
