223677-08-5Relevant articles and documents
Design and synthesis of thiol containing inhibitors of matrix metalloproteinases
Fink, Cynthia A.,Carlson, J. Eric,Boehm, Charles,McTaggart, Patricia,Qiao, Ying,Doughty, John,Ganu, Vishwas,Melton, Richard,Goldberg, Ronald
, p. 195 - 200 (2007/10/03)
A series of thiol containing derivatives was prepared. Several of these compounds were found to inhibit matrix metalloproteinases 1, 3, and 9 with selectivity towards 3 and 9. Compounds 15, 20 and 22 were administered to rats orally at 75 μmol/kg. Drug levels of compounds 20 and 22 in the plasma were found to exceed the IC50 values for MMP 3 and 9 four hours after administration.