22368-21-4

Basic information

• Product Name: eupatilin
• Synonyms: eupatilin;2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one;5,7-Dihydroxy-3',4',6-trimethoxyflavone;2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one;4H-1-Benzopyran-4-one, 2-(3,4-diMethoxyphenyl)-5,7-dihydroxy-6-Methoxy-;Eupatilin 2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one;2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one;2-(3,4-dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one (EUPATILIN)
• CAS NO: 22368-21-4
• Molecular Formula: C₁₈H₁₆O₇
• Molecular Weight: 344.31
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 22368-21-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 236-238 °C
• Boiling Point: 583.6 °C at 760mmHg
• Flash Point: 214.7 °C
• Appearance: /
• Density: 1.387 g/cm³
• Vapor Pressure: 3.21E-14mmHg at 25°C
• Refractive Index: 1.627
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• Solubility: Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
• PKA: 6.47±0.40(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: eupatilin(CAS DataBase Reference)
• NIST Chemistry Reference: eupatilin(22368-21-4)
• EPA Substance Registry System: eupatilin(22368-21-4)

Safety Data

• Hazardous Substances Data: 22368-21-4(Hazardous Substances Data)

Usage

Uses

Eupatilin maintains anticoagulant and antiplatelet activity isolated from the Artemisia princeps Pampanini flower.

Definition

ChEBI: A trimethoxyflavone with flavone substituted by hydroxy groups at C-5 and C-7 and methoxy groups at C-6, C-3' and C-4' respectively. Isolated from Citrus reticulata and Salvia tomentosa, it exhibits anti-inflammatory, anti-ulcer a d antineoplastic activities.

InChI:InChI=1/C18H16O7/c1-22-12-5-4-9(6-14(12)23-2)13-7-10(19)16-15(25-13)8-11(20)18(24-3)17(16)21/h4-8,20-21H,1-3H3

Upstream product

• 870480-47-0 2,6-diacetyl-3,4,5-trimethoxyphenol 
• 52378-71-9 7-(benzyloxy)-2-(3,4-dimethoxyphenyl)-6,7-dimethoxy-4H-chromen-4-one 
• 52378-70-8 (E)-1-(4-Benzyloxy-6-hydroxy-2,3-dimethoxy-phenyl)-3-(3,4-dimethoxy-phenyl)-propenone 
• 25892-95-9 1-(4-(benzyloxy)-6-hydroxy-2,3-dimethoxyphenyl)ethan-1-one 
• 25892-94-8 1-(4-(benzyloxy)-3,6-dihydroxy-2-methoxyphenyl)ethan-1-one 
• 39548-89-5 1-(4-(benzyloxy)-2-hydroxy-6-methoxyphenyl)ethan-1-one 
• 681294-57-5 1-(4-(benzyloxy)-2-hydroxy-6-methoxyphenyl)ethanone 
• 110506-85-9 7-(benzyloxy)-5-hydroxy-2-phenyl-4H-chromen-4-one 
• 480-40-0 5,7-dihydroxy-2-phenyl-chromen-4-one 
• 40983-99-1 2-(3,4-dimethoxyphenyl)-7-hydroxy-5,6-dimethoxy-4H-chromen-4-one 

Downstream Products

• 203191-05-3 7-carboxymethyloxy-5-hydroxy-3',4',6-trimethoxy flavone 

Relevant articles and documents

Novel compound and composition for prevention, improvement or treatment of fibrosis or non-alcoholic steatohepatitis comprising the same

The present invention relates to a novel compound and a composition for prevention, improvement, or treatment of fibrosis or nonalcoholic steatohepatitis comprising the same as an active ingredient. More specifically, the present invention relates to a novel compound of chemical formula 1 which has an excellent effect for prevention, improvement, or treatment of fibrosis and a composition for prevention, improvement, or treatment of fibrosis or nonalcoholic steatohepatitis comprising the same as an active ingredient. A novel compound of the present invention effectively controls expression of snail and vimentin which are a controlling element of Epithelial Mesenchymal Transition (EMT) and controls activation of EMT, and thus effectively prevents, improves, or treats fibrosis accordingly. Additionally, a novel compound of the present invention has a very excellent pharmacokinetic characteristic, and thus can perform fast drug delivery to the body through oral administration, stably displays an effect in the body, and is secure to use without a big side effect. Moreover, since a novel compound of the present invention can effectively block fibrosis of a hepatic cell, nonalcoholic steatohepatitis can effectively improved or treated.(AA) Chemical formula 1COPYRIGHT KIPO 2018

5, 7-dihydroxy-6-production of polymethoxyflavones

PROBLEM TO BE SOLVED: To provide an efficient production method of 5,7-dihydroxy-6-methoxyflavones in a short step. SOLUTION: The production method of 5,7-dihydroxy-6-methoxyflavones includes a step of demethylating 5,6,7-trimethoxy-8-acylflavones expressed by general formula (II). In the formula, n represents an integer of 0 to 5; R2represents a hydroxyl group or the like and when n is 2 or more, a plurality of R2may be the same or different from each other; and R3represents a 1-4C straight-chain or branched alkyl group or the like. COPYRIGHT: (C)2012,JPOandINPIT