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480-40-0 Usage

Chemical Description

Chrysin is a flavone found in honey and propolis.


Chrysin is a natural flavonoid with antioxidant, anti-inflammatory, and anticancer properties. It is a dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7. Chrysin blocks COX-2 gene expression, PGE2 production, and hydroxyl radical formation in LPS-induced RAW 264.7 cells. It inhibits insulin-induced HIF-1α expression in human prostate cancer DU145 cells and blocks DU145 xenograft-induced angiogenesis in vivo. In a mouse model of ischemia/reperfusion injury, chrysin decreased pro-inflammatory gene expression and oxidative stress, resulting in a reduction of infarct volume and neurological defects. It is also a central benzodiazepine receptor ligand with possible anxiolytic effects, although it was initially believed to have aromatase inhibitor properties, which recent in vivo studies have disproved. Chrysin appears as a beige powder.


Used in Pharmaceutical Applications:
Chrysin is used as an anti-inflammatory agent for its potential protective effects against cancer and cardiovascular disease. It is also used as an anxiolytic agent due to its central benzodiazepine receptor ligand properties.
Used in Dyes and Metabolites:
Chrysin is used in the production of dyes and as a component in the synthesis of various metabolites.
Used in Research and Development:
Chrysin is utilized in research for its antioxidant, anti-inflammatory, and anticancer properties, as well as its potential applications in the development of new drugs and therapies.


The main sources of chrysin are honey and propolis, of which the content of chrysin in honey is 5.3 mg/kg?and that in propolis is 28 g/L. In addition, chrysin is also found in various vegetables, fruits, herbs, and even mushrooms?[10]. Another source of populin is an endophytic fungus Chaetomium globosum, which is related to Chaetomorpha media from India. In addition, chrysin exists in the form of glycosides in walnut, walnut skin, walnut flower and pericarp passion fruit, and in the form of 6-c-arabinoside-8-c-glucoside or glucuronic acid ester in Pinellia ternata.

Check Digit Verification of cas no

The CAS Registry Mumber 480-40-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 0 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 480-40:
60 % 10 = 0
So 480-40-0 is a valid CAS Registry Number.

480-40-0 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (C1652)  Chrysin  >98.0%(HPLC)(T)

  • 480-40-0

  • 25g

  • 845.00CNY

  • Detail
  • Alfa Aesar

  • (L14178)  5,7-Dihydroxyflavone, 98%   

  • 480-40-0

  • 5g

  • 340.0CNY

  • Detail
  • Alfa Aesar

  • (L14178)  5,7-Dihydroxyflavone, 98%   

  • 480-40-0

  • 25g

  • 860.0CNY

  • Detail
  • Sigma-Aldrich

  • (95082)  Chrysin  analytical standard

  • 480-40-0

  • 95082-50MG

  • 1,100.97CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017


1.1 GHS Product identifier

Product name chrysin

1.2 Other means of identification

Product number -
Other names 5,7-Dihydroxyflavone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:480-40-0 SDS

480-40-0Relevant articles and documents

Oxidation of Flavone, 5-Hydroxyflavone, and 5,7-Dihydroxyflavone to Mono-, Di-, and Tri-Hydroxyflavones by Human Cytochrome P450 Enzymes

Nagayoshi, Haruna,Murayama, Norie,Kakimoto, Kensaku,Tsujino, Masaki,Takenaka, Shigeo,Katahira, Jun,Lim, Young-Ran,Kim, Donghak,Yamazaki, Hiroshi,Komori, Masayuki,Guengerich, F. Peter,Shimada, Tsutomu

, p. 1268 - 1280 (2019)

Biologically active plant flavonoids, including 5,7-dihydroxyflavone (57diOHF, chrysin), 4′,5,7-trihydroxyflavone (4′57triOHF, apigenin), and 5,6,7-trihydroxyflavone (567triOHF, baicalein), have important pharmacological and toxicological significance, e.g., antiallergic, anti-inflammatory, antioxidative, antimicrobial, and antitumorgenic properties. In order to better understand the metabolism of these flavonoids in humans, we examined the oxidation of flavone, 5-hydroxyflavone (5OHF), and 57diOHF to various products by human cytochrome P450 (P450 or CYP) and liver microsomal enzymes. Individual human P450s and liver microsomes oxidized flavone to 6-hydroxyflavone, small amounts of 5OHF, and 11 other monohydroxylated products at different rates and also produced several dihydroxylated products (including 57diOHF and 7,8-dihydroxyflavone) from flavone. We also found that 5OHF was oxidized by several P450 enzymes and human liver microsomes to 57diOHF and further to 567triOHF, but the turnover rates in these reactions were low. Interestingly, both CYP1B1.1 and 1B1.3 converted 57diOHF to 567triOHF at turnover rates (on the basis of P450 contents) of >3.0 min-1, and CYP1A1 and 1A2 produced 567triOHF at rates of 0.51 and 0.72 min-1, respectively. CYP2A13 and 2A6 catalyzed the oxidation of 57diOHF to 4′57triOHF at rates of 0.7 and 0.1 min-1, respectively. Our present results show that different P450s have individual roles in oxidizing these phytochemical flavonoids and that these reactions may cause changes in their biological and toxicological properties in mammals.

Novel chromenone derivatives having substituted biphenyl group and a pharmaceutical composition for prevention or treatment of allergic diseases compring the same


, (2020/11/26)

The present invention relates to: a novel chromenone derivative compound capable of effectively suppressing an allergic immune response by inhibiting signal transduction mediated by thymic stromal lymphopoietin (TSLP); and a pharmaceutical composition capable of fundamentally preventing or treating various allergic diseases by using the same.COPYRIGHT KIPO 2021

Design, synthesis and biological evaluation of 2-Phenyl-4H-chromen-4-one derivatives as polyfunctional compounds against Alzheimer’s disease

Singh, Manjinder,Kaur, Maninder,Vyas, Bhawna,Silakari, Om

, p. 520 - 530 (2017/10/09)

Polyfunctional compounds comprise a novel class of therapeutic agents for the treatment of multi-factorial diseases. A series of 2-Phenyl-4H-chromen-4-one and its derivatives (5a–n) were designed, synthesized, and evaluated for their poly-functionality against acetylcholinestrase (AChE) and advanced glycation end products (AGEs) formation inhibitors against Alzheimer’s disease (AD). The screening results showed that most of them exhibited a significant ability to inhibit AChE AGEs formation with additional radical scavenging activity. Especially, 5m, 5b, and 5j displayed the greatest ability to inhibit AChE (IC50 = 8.0, 8.2, and 11.8 nM, respectively) and AGEs formation (IC50 = 55, 79, and 54 μM, respectively) with good antioxidant activity. Molecular docking studies explored the detailed interaction pattern with active, peripheral, and mid-gorge sites of AChE. These compounds, exhibiting such multiple pharmacological activities, can be further taken a lead for the development of potent drugs for the treatment of Alzheimer’s disease.

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