223690-44-6

Basic information

• Product Name: 5,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid
• Synonyms: 5,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid
• CAS NO: 223690-44-6
• Molecular Formula: C₁₀H₅F₂NO₃
• Molecular Weight: 225.15
• Mol File: 223690-44-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 390°C at 760 mmHg
• Flash Point: 189.6°C
• Appearance: /
• Density: 1.653g/cm³
• Vapor Pressure: 8.84E-07mmHg at 25°C
• Refractive Index: 1.672
• CAS DataBase Reference: 5,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid(223690-44-6)
• EPA Substance Registry System: 5,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid(223690-44-6)

Safety Data

• Hazardous Substances Data: 223690-44-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H5F2NO3/c11-5-1-2-6(12)8-7(5)9(14)4(3-13-8)10(15)16/h1-3H,(H,13,14)(H,15,16)

Upstream product

• 185011-67-0 ethyl 5,8-difluoro-4-hydroxy-3-quinolinecarboxylate 
• 185010-73-5 diethyl 2-(((2,5-difluorophenyl)amino)methylene)malonate 
• 367-30-6 2,5-difluoroaniline 

Downstream Products

• 228726-31-6 N-(4-chlorobenzyl)-8-fluoro-4-hydroxy-6-(5-hydroxy-1-pentynyl)-3-quinolinecarboxamide 
• 228726-33-8 methyl 3-(((4-Chlorobenzyl)amino)carbonyl)-8-fluoro-4-hydroxy-6-quinolinecarboxylate 

Relevant articles and documents

4-HYDROXYQUINOLINE-3-CARBOXAMIDES AND HYDRAZIDES AS ANTIVIRAL AGENTS

The present invention provides 4-hydroxyquinoline-3-carboxamide and hydrazide compounds of formula I These compounds are useful to treat or prevent the herpesviral infections, particularly, human cytomegaloviral infection.

Synthesis of fluoro-4-hydroxyquinoline-3-carboxylic acids by the Gould-Jacobs reaction

The synthesis of several fluoro-4-hydroxyquinoline-3-carboxylic acids by the Gould-Jacobs reaction is presented. These quinolines are important intermediates for the preparation of antibacterial fluoroquinolones.