223697-44-7Relevant articles and documents
Design, synthesis, and structure-activity relationships of potent GPIIb/IIIa antagonists: Discovery of FK419
Yamanaka, Toshio,Ohkubo, Mitsuru,Kuroda, Satoru,Nakamura, Hideko,Takahashi, Fumie,Aoki, Toshiaki,Mihara, Kayoko,Seki, Jiro,Kato, Masayuki
, p. 4343 - 4352 (2005)
The discovery of the non-peptide antiplatelet injectable agent FK419 is reported. Based on the β-turn structure of RGD peptide sequences in the α chain of fibrinogen, which binds the glycoprotein IIb/IIIa (GPIIb/IIIa) on the surface of platelets to induce