223757-48-0

Upstream product

• 6515-21-5 4-methoxymethoxy-benzaldehyde 
• 123-08-0 4-hydroxy-benzaldehyde 
• 25458-45-1 p-methoxymethoxybromobenzene 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 142039-75-6 4-(Methoxymethoxy)benzylamine 
• 51517-88-5 5-(4-hydroxyphenyl)-1H-1,2,3,4-tetrazole 
• 223757-44-6 N-[4-(4-methoxy-benzyl)-1-(4-methoxymethoxy-benzyl)-5-oxo-4,5-dihydro-1H-imidazol-2-yl]-4-methyl-benzenesulfonamide 
• 223757-42-4 5-hydroxy-4-(4-methoxybenzyl)-1-(4-methoxymethylenoxy)benzyl-2-tosylamino-4,5-dihydroimidazole 
• 223757-41-3 N-[4-(4-methoxy-benzyl)-1-(4-methoxymethoxy-benzyl)-1H-imidazol-2-yl]-4-methyl-benzenesulfonamide 
• 223757-33-3 1,4-bis(4-hydroxybenzyl)-2-tosylaminoimidazole 
• 110189-02-1 4-[2-amino-1-(4-hydroxybenzyl)-1H-imidazol-4-ylmethyl]phenol 

Relevant academic research and scientific papers

Facile one-pot preparation of 5-aryltetrazoles and 3-arylisoxazoles from aryl bromides

The successive treatment of aryl bromides with n-BuLi, DMF, hydroxylamine hydrochloride, and finally diphenylphosphoryl azide provided efficiently the corresponding 5-aryltetrazoles in good to moderate yields. Similarly, the successive treatment of aryl bromides with n-BuLi, DMF, hydroxylamine hydrochloride, and finally diethyl acetylenedicarboxylate and Oxone provided efficiently the corresponding diethyl 3-arylisoxazole-4,5-dicarboxylates in good to moderate yields. Aromatic aldoximes are the key intermediates in both reactions, and 5-aryltetrazoles and 3-arylisoxazoles could be obtained from aryl bromides in one pot under transition-metal-free conditions.