223769-30-0

Upstream product

• 122-39-4 diphenylamine 
• 319-61-9 (S)-1-(trifluoroacetyl)pyrrolidine-2-carboxylic acid 
• 223769-31-1 (S)-1-(2,2,2-Trifluoro-acetyl)-pyrrolidine-2-carboxylic acid diphenylamide 
• 36724-68-2 (S)-N-trifluoroacetylproline acid chloride 
• 132139-15-2 (S)-N,N-diphenyl-2-pyrrolidinecarboxamide 
• 224784-84-3 (S)-(+)-N-tert-butoxycarbonyl-2-<(N',N'-diphenylamino)methyl>pyrrolidine 

Relevant academic research and scientific papers

Enantioselective synthesis of binaphthol derivatives by oxidative coupling of naphthol derivatives catalyzed by chiral diamine-copper complexes

A highly efficient process of aerobic oxidative coupling of 2-naphthol derivatives catalyzed by 1 mol % of Cu(OH)Cl·TMEDA has been developed. Enantioselective oxidative coupling of naphthols was achieved by the use of 10 mol % of chiral catalysts prepared from proline-derived diamines and cuprous chloride, affording the corresponding binaphthols in good enantioselectivities of up to 78% ee. The ester moiety at the 3-position of the substrate was found to be essential for the good asymmetric induction observed in the present coupling reaction.

An asymmetric conjugate addition reaction of lithium organocopper reagent controlled by a chiral amidophosphine

Examination of the behaviors of the chiral amidophosphines 1-14 in the asymmetric conjugate addition reaction of lithium organocopper with chalcone and cycloalkenone revealed that the reaction efficiency is governed by many factors including copper salt, solvent, molecular ratio of copper and organolithium, and the structure of the substrate. The reaction with cycloalkenone gave the adduct in up to 94% ee under the stoichiometric conditions.