22377-14-6Relevant academic research and scientific papers
Zinc carbenoid-mediated chain extension of β-keto amides
Hilgenkamp, Ramona,Zercher, Charles K
, p. 8793 - 8800 (2007/10/03)
The reaction of β-keto amides with ethyl(iodomethyl)zinc provides access to a wide variety of γ-keto amides, including primary, secondary, and tertiary amides. Although the reaction of α-substituted β-keto amides are in many cases unsatisfactory, the method can be applied to a broad spectrum of substrates that possess imide and olefinic functionality.
Study of photochemical addition of acyl radical to electron-deficient olefins
Macias,Molinillo,Massanet,Rodriguez-Luis
, p. 3345 - 3352 (2007/10/02)
The photochemical addition of acyl radical to electron-deficient olefins is studied. The scope of the reaction, the mechanism, the role that molecular oxygen plays, the influence of steric effects, and the side reaction that take place are discussed. The reaction was carried out using a range of electron-withdrawing substituents (ketones, amides, lactones, nitrile and esters) with good yields of the corresponding photoadduct in all cases.
An efficient and mild entry to 1,4-dicarbonyl compounds via photochemical addition of acyl radical to electron-deficient olefins
Macias, Francisco A.,Molinillo, Jose Maria G.,Collado, Isidro G.,Massanet, Guillermo M.,Rodriguez-Luis, Francisco
, p. 3063 - 3066 (2007/10/02)
Photoehcmical addition of acetaldehyde to electron-deficient olefins in the presence of molecular oxygen provides an efficient and mild method for the synthesis of 1,4-functionallzed compounds. Some considerations about the mechanism and the substituent effects are outlined.
