223786-22-9

Basic information

• Product Name: 1H-1,4-Diazepine, hexahydro-1-methyl-4-(4-nitrophenyl)-
• CAS NO: 223786-22-9
• Molecular Formula: C12H17N3O2
• Molecular Weight: 235.286
• Mol File: 223786-22-9.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 1H-1,4-Diazepine, hexahydro-1-methyl-4-(4-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-1,4-Diazepine, hexahydro-1-methyl-4-(4-nitrophenyl)-(223786-22-9)
• EPA Substance Registry System: 1H-1,4-Diazepine, hexahydro-1-methyl-4-(4-nitrophenyl)-(223786-22-9)

Safety Data

• Hazardous Substances Data: 223786-22-9(Hazardous Substances Data)

Usage

Heterocyclic ring structure

The compound has a ring structure that contains both nitrogen and carbon atoms.

Diazepine family

It is a member of the diazepine family, which is a group of chemical compounds.

Hexahydro substitution

The compound has a hexahydro (six hydrogen atoms) substitution.

1-methyl-4-(4-nitrophenyl)substitution

The compound has a methyl group at the 1st position and a 4-nitrophenyl group at the 4th position of the heterocyclic ring.

Pharmaceutical research

It is commonly used in pharmaceutical research.

Potential biological activity

It is known for its potential biological activity.

Safety protocols

It is important to handle this chemical with care and to follow proper safety protocols when working with it in a laboratory setting.

Upstream product

• 350-46-9 4-Fluoronitrobenzene 
• 220220-23-5 tert-butyl 4-(4-nitrophenyl)-1,4-diazepane-1-carboxylate 
• 112275-50-0 tert-butyl 1,4-diazepine-1-carboxylate 
• 50-00-0 formaldehyd 
• 214124-83-1 1-(4-nitrophenyl)-[1,4]diazepane 
• 4318-37-0 1-Methylhomopiperazine 
• 586-78-7 para-nitrophenyl bromide 
• 505-66-8 1,4-Diazacycloheptane 
• 74-88-4 methyl iodide 

Downstream Products

• 771584-75-9 tert-butyl ({[(7-cyano-2-naphthyl)methyl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)carbamate 
• 771584-97-5 ({((2E)-3-{3-[amino(hydroxyimino)methyl]phenyl}prop-2-en-1-yl)[4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetic acid 
• 771584-76-0 tert-butyl ({[(7-cyano-2-naphthyl)methyl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)methylcarbamate 
• 771584-91-9 ethyl ({((2E)-3-{3-[amino(imino)methyl]phenyl}prop-2-en-1-yl)[4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate 
• 714249-31-7 ethyl ({[(7-cyano-2-naphthyl)methyl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate 
• 771584-78-2 ethyl ({[(7-cyano-2-naphthyl)methyl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)carbamate 
• 771584-88-4 ethyl ({[(2E)-3-(3-cyanophenyl)prop-2-en-1-yl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate 
• 771584-89-5 isopropyl ({[(2E)-3-(3-cyanophenyl)prop-2-en-1-yl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate 

Relevant articles and documents

MACROCYCLIC COMPOUND SERVING AS WEE1 INHIBITOR AND APPLICATIONS THEREOF

Disclosed in the present invention are a macrocyclic compound serving as a Weel inhibitor, and applications thereof in the preparation of drugs for treating Weel-related diseases. The present invention specifically relates to a compound represented by for

Structure-Bioactivity Relationships of Lapatinib Derived Analogs against Schistosoma mansoni

We recently reported a series of compounds for a solubility-driven optimization campaign of antitrypanosomal compounds. Extending a parasite-hopping approach to the series, a subset of compounds from this library has been cross-screened for activity against the metazoan flatworm parasite, Schistosoma mansoni. This study reports the identification and preliminary development of several potently bioactive compounds against adult schistosomes, one or more of which represent promising leads for further assessment and optimization.

Design and synthesis of 4-(Heterocyclic substituted amino)-1h-pyrazole-3-carboxamide derivatives and their potent activity against acute myeloid leukemia (AML)

Fms-like receptor tyrosine kinase 3 (FLT3) has been emerging as an attractive target for the treatment of acute myeloid leukemia (AML). By modifying the structure of FN-1501, a potent FLT3 inhibitor, 24 novel 1H-pyrazole-3-carboxamide derivatives were designed and synthesized. Compound 8t showed strong activity against FLT3 (IC50: 0.089 nM) and CDK2/4 (IC50: 0.719/0.770 nM), which is more efficient than FN-1501(FLT3, IC50: 2.33 nM; CDK2/4, IC50: 1.02/0.39 nM). Compound 8t also showed excellent inhibitory activity against a variety of FLT3 mutants (IC50 50: 1.22 nM). In addition, compound 8t significantly inhibited the proliferation of most human cell lines of NCI60 (GI50 1 μM for most cell lines). Taken together, these results demonstrated the potential of 8t as a novel compound for further development into a kinase inhibitor applied in cancer therapeutics.