223787-31-3

Basic information

• Product Name: N-(2-benzoyl-4-chlorophenyl)-3-cyclohexylpropanamide
• Synonyms: N-(2-benzoyl-4-chlorophenyl)-3-cyclohexylpropanamide
• CAS NO: 223787-31-3
• Molecular Formula: C22H24ClNO2
• Molecular Weight: 369.88446
• Mol File: 223787-31-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2-benzoyl-4-chlorophenyl)-3-cyclohexylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-benzoyl-4-chlorophenyl)-3-cyclohexylpropanamide(223787-31-3)
• EPA Substance Registry System: N-(2-benzoyl-4-chlorophenyl)-3-cyclohexylpropanamide(223787-31-3)

Safety Data

• Hazardous Substances Data: 223787-31-3(Hazardous Substances Data)

Upstream product

• 719-59-5 5-chloro-2-aminobenzophenone 
• 39098-75-4 3-cyclohexylpropionyl chloride 

Relevant articles and documents

Different amino acid replacements in CAAX-tetrapeptide based peptidomimetic farnesyltransferase inhibitors

In a series of CAAX-tetrapeptide based farnesyltransferase inhibitors it has been shown that the central AA-dipeptide can be replaced by tranexamic acid, 4-aminobenzenesulfonic acid, and 3-amino-N-(2,3- dimethylphenyl)benzenesulfonamide, respectively, yielding inhibitors active in the low micromolar range. Lipophilic derivatives of these compounds showed moderate antiproliferative activity against different tumor cell lines. A promising class of peptidomimetic farnesyltransferase inhibitors was discovered through the replacement of the terminal AAX motif of the CAAX- tetrapeptide by 2-acylamino-5-aminobenzophenones.