223788-08-7Relevant academic research and scientific papers
1,7-naphthyridine derivative, preparation method and applications thereof
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Paragraph 0166; 0167; 0170; 0171, (2020/03/23)
The present invention relates to a compound represented by a formula (I) or a tautomer, an optical isomer, a nitrogen oxide, a solvate, a pharmaceutically acceptable salt or a prodrug thereof, a preparation method of the compound, a pharmaceutical composi
NEW PYRIDINE ANALOGUES VIII 518
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Page/Page column 212, (2008/12/07)
The present invention relates to certain new pyridin analogues of Formula ( I ) to processes for preparing such compounds, to their utility as P2Y12 inhibitors and as anti-trombotic agents etc, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.
Biaryl substituted alkylboronate esters as thrombin inhibitors
Quan,Wityak,Dominguez,Duncia,Kettner,Ellis,Liauw,Park,Santella,Knabb,Thoolen,Weber,Wexler
, p. 1595 - 1600 (2007/10/03)
Thrombin is a serine protease that plays an important role in the blood coagulation cascade, and is a target enzyme for new therapeutic agents. Ac- (D)-Phe-Pro-boroArg-OH (DuP 714) was found to be a highly effective thrombin inhibitor. In order to reduce the peptidic nature of DuP 714, we have designed a series of novel biaryl substituted alkylboronate esters as potent thrombin inhibitors. The most potent compounds have subnanomolar affinity for thrombin.
