22388-90-5Relevant academic research and scientific papers
Interchenar retrotransfer of aureothin intermediates in an iterative polyketide synthase module
Busch, Benjamin,Ueberschaar, Nico,Sugimoto, Yuki,Hertweck, Christian
, p. 12382 - 12385 (2012)
The course of the enigmatic iterative use of a polyketide synthase module was deduced from targeted domain inactivation in the aureothin assembly line. Mutational analyses revealed that the N-terminus of AurA is not involved in the iteration process, ruli
Regioselective functionalization of pyrones: Facile synthesis of 6-styrylpyrones via KHMDS-mediated aldol condensation
Basu, Manas K.,Mukkanti, K.,Samala, Ramakrishna
supporting information, (2022/01/03)
Herein, we disclose our efforts directed toward the synthesis of the kavalactone-based natural product penstyrylpyrone and other related 4-OMe-2-pyrones possessing diverse substituents at the 3-, 5-, and 7-positions. Further, a facile approach to access 6-styrylpyrones via the KHMDS-mediated regioselective aldol condensation of 2-pyrones is described with moderate substrate scope and good to high yields (58–80%). The utility of this methodology was exemplified by the stereoselective construction of desmethoxyyangonin, asnipyrone A, and asnipyrone B.
Multifactorial control of iteration events in a modular polyketide assembly line
Busch, Benjamin,Ueberschaar, Nico,Behnken, Swantje,Sugimoto, Yuki,Werneburg, Martina,Traitcheva, Nelly,He, Jing,Hertweck, Christian
, p. 5285 - 5289 (2013/06/26)
Freedom and control: First insights into the rare programmed iteration of an individual polyketide synthase (PKS) module were obtained from the analysis and mutation of aureothin (1) synthase. The first ketosynthase (KS) domain primes the PKS, allowing intermediate retrotransfer. Addition of a designated loading module results in a complete loss of iteration. The downstream KS functions as a gatekeeper for correct chain length. Copyright
