22388-91-6

Upstream product

• 58550-34-8 (E)-2-methyl-3-(4-nitrophenyl)acrylaldehyde 
• 21382-82-1 (carbethoxyethylidene)triphenylphosphorane 
• 37542-81-7 (2E)-2-methyl-3-(4-nitrophenyl)prop-2-en-1-ol 
• 30018-16-7 (1-ethoxycarbonylethyl)triphenylphosphonium bromide 
• 53618-29-4 (E)-ethyl 2-methyl-3-(4-nitrophenyl)acrylate 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 59488-85-6 (2E,4E)-2,4-dimethyl-5-(4-nitrophenyl)penta-2,4-dienol 
• 59488-84-5 (2E,4E)-2,4-dimethyl-5-(p-nitrophenyl)pentan-2,4-dienal 
• 78847-04-8 (2E,4E,6E)-2,4,6-trimethyl-7-(4-nitro-phenyl)-hepta-2,4,6-trienal 
• 648414-16-8 (2E,4E,6E)-2,4,6-trimethyl-7-(4-nitrophenyl)hepta-2,4,6-trien-1-ol 
• 476418-12-9 ethyl (2E,4E,6E)-2,4,6-trimethyl-7-(4-nitrophenyl)hepta-2,4,6-trienoate 
• 476418-18-5 (2E,4E,6E,8E)-4,6,8-trimethyl-9-(4-nitro-phenyl)-nona-2,4,6,8-tetraenoic acid methyl ester 
• 476418-14-1 (2E,4E,6E,8E)-4,6,8-trimethyl-9-(4-nitro-phenyl)-nona-2,4,6,8-tetraenoic acid ethyl ester 
• 627079-61-2 (2E,4E,6E,8E)-2,4,6,8-tetramethyl-9-(4-nitrophenyl)nona-2,4,6,8-tetraenal 
• 648414-22-6 (2E,4E,6E,8E)-2,4,6,8-Tetramethyl-9-(4-nitro-phenyl)-nona-2,4,6,8-tetraen-1-ol 
• 627079-60-1 ethyl (2E,4E,6E,8E)-2,4,6,8-tetramethyl-9-(4-nitrophenyl)nona-2,4,6,8-tetraenoate 
• 627079-62-3 ethyl (2E,4E,6E,8E,10E)-4,6,8,10-tetramethyl-11-(4-nitrophenyl)undeca-2,4,6,8,10-pentaenoate 
• 22388-90-5 (2E,4E)-2,4-dimethyl-5-(4-nitrophenyl)penta-2,4-dienoic acid 
• 1440522-77-9 (2E,4E,6E,8E)-2,4,6,8-tetramethyl-9-(4-nitrophenyl)nona-2,4,6,8-tetraenoic acid 

Relevant academic research and scientific papers

Studies on the biomimetic synthesis of SNF4435 C and D

(equation Presented) The biomimetic synthesis of the bicyclic core of the novel immunosuppresants SNF4435C and SNF4435D is reported. The core framework was efficiently generated from the all-trans tetraene precursor in one step and in good yield.

Multifactorial control of iteration events in a modular polyketide assembly line

Freedom and control: First insights into the rare programmed iteration of an individual polyketide synthase (PKS) module were obtained from the analysis and mutation of aureothin (1) synthase. The first ketosynthase (KS) domain primes the PKS, allowing intermediate retrotransfer. Addition of a designated loading module results in a complete loss of iteration. The downstream KS functions as a gatekeeper for correct chain length. Copyright

Interchenar retrotransfer of aureothin intermediates in an iterative polyketide synthase module

The course of the enigmatic iterative use of a polyketide synthase module was deduced from targeted domain inactivation in the aureothin assembly line. Mutational analyses revealed that the N-terminus of AurA is not involved in the iteration process, ruli

PHARMACEUTICAL AGENTS

Use of compounds of formula (I) in the manufacture of a medicament for use in treating a disorder mediated by histone deacetylase: wherein the symbol ---- represents a single bond or a double bond or the symbol ---- R6 and R8 togethe

Biomimetic studies on polyenes.

The crispatenes and SNF4435 C&D are complex polypropionate derived natural products. The core structures of these compounds along with a complex unnatural structure can be easily prepared from a common polyene precursor simply by variation of the reaction conditions. The reaction pathways provide insight into the biosynthesis of these complex natural products.