223906-81-8Relevant academic research and scientific papers
Inhibition of γ-secretase by the CK1 inhibitor IC261 does not depend on CK1δ
H?ttecke, Nicole,Liebeck, Miriam,Baumann, Karlheinz,Schubenel, Robert,Winkler, Edith,Steiner, Harald,Schmidt, Boris
, p. 2958 - 2963 (2010)
CK1 and γ-secretase are interesting targets for therapeutic intervention in the treatment of cancer and Alzheimer's disease. The CK1 inhibitor IC261 was reported to inhibit γ-secretase activity. The question is: Does CK1 inhibition directly influence γ-se
Facile convergent route to indoloquinolines
Kadam, Hari K.,Malik, Deesha D.,Salgaonkar, Lalitprabha,Mandrekar, Ketan,Tilve, Santosh G.
, p. 1980 - 1984 (2017/09/27)
A convergent route to indoloquinolines is developed through aldol condensation. This two-step method utilizes commercially available 2-oxoindole and o-nitrobenzaldehyde as starting materials. Chromatography-free method is accomplished for preparing several derivatives of indoloquinolines with desirable aromatic substitutions on indole as well as quinoline ring.
