22395-53-5

Upstream product

• 1374869-98-3 6,7-dimethoxy-2-methyl-1-(phenylethynyl)-1,2,3,4-tetrahydroisoquinoline 
• 536-74-3 phenylacetylene 
• 102921-26-6 (1,2-dibromoethyl)benzene 
• 621-82-9 Cinnamic acid 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 50-00-0 formaldehyd 
• 123279-35-6 (1R)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1-(2-phenyl-1-ethyl)-isoquinoline 
• 56361-03-6 N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenylacrylamide 
• 81305-67-1 3,4-dihydro-6,7-dimethoxy-1-(2-phenylethyl)isoquinoline 
• 2878-60-6 N-(3,4-dimethoxyphenethyl)-3-phenylpropanamide 

Relevant academic research and scientific papers

Biomimetic Total Synthesis of Dysoxylum Alkaloids

A five-step total synthesis of Dysoxylum alkaloids has been achieved using a biomimetic approach from zanthoxylamide protoalkaloids. The synthesis featured a direct amidation and a Bischler-Napieralski reaction to form the dihydroisoquinoline ring, which

C-1 alkynylation of N-methyltetrahydroisoquinolines through CDC: A direct access to phenethylisoquinoline alkaloids

Direct cross-coupling between N-methyltetrahydroisoquinolines and alkynes using CuI-DEAD is presented. It affords the regioselective C-1-alkynylated products in good yield. This regio-selectivity is in contrast to the results reported earlier in the reaction of N,N-dimethylbenzyl amine where the N-methyl alkynylated product was formed exclusively or predominantly. The C-1-substituted propargylic isoquinolines were easily reduced to phenethylisoquinolines with Pd/C. This reaction sequence provides a short route to synthesize methopholine, homolaudanosine and other phenethylisoquinoline alkaloids. Georg Thieme Verlag Stuttgart · New York.