224044-67-1 Usage
Uses
Used in Cosmetics Industry:
(2E)-4-(3-Hydroxy-2-nitrophenyl)-4-oxo-2-butenoic Acid Methyl Ester is used as an ingredient in the preparation of human UV filters for the cosmetics industry. Its application reason is to provide protection against harmful ultraviolet (UV) radiation, which can cause skin damage, premature aging, and increase the risk of skin cancer. The compound's ability to absorb and dissipate UV radiation makes it a valuable component in the formulation of sunscreens and other skincare products designed to shield the skin from the sun's harmful effects.
Used in Pharmaceutical Industry:
While not explicitly mentioned in the provided materials, due to its chemical structure and properties, (2E)-4-(3-Hydroxy-2-nitrophenyl)-4-oxo-2-butenoic Acid Methyl Ester may also have potential applications in the pharmaceutical industry. It could be utilized in the development of new drugs or drug delivery systems, taking advantage of its chemical reactivity and functional groups for various therapeutic purposes. However, further research and development would be necessary to explore and validate these potential applications.
Check Digit Verification of cas no
The CAS Registry Mumber 224044-67-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,4,0,4 and 4 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 224044-67:
(8*2)+(7*2)+(6*4)+(5*0)+(4*4)+(3*4)+(2*6)+(1*7)=101
101 % 10 = 1
So 224044-67-1 is a valid CAS Registry Number.
224044-67-1Relevant academic research and scientific papers
Synthesis of Human Ultraviolet Filter Compounds: O-β-D-Glucopyranosides of 3-Hydroxykynurenine and 2-Amino-3-hydroxy-γ-oxobenzenebutanoic Acid
Manthey, Michael K.,Jamie, Joanne F.,Truscott, Roger J. W.
, p. 3930 - 3933 (2007/10/03)
The role of endogenous tryptophan-derived UV filters in aging lenses and in human cataract is becoming increasingly important. The two major UV filters found in the lenses of primates, the O-β-D-glucopyranosides of 3-hydroxykynurenine and 2-amino-3-hydroxy-γ-oxobenzenebutanoic acid, 1 and 2, were synthesized from the common benzoyl acrylate precursor 2-amino-3-hydroxybenzoyl-acrylic acid 10. Synthesis of compound 3, the α-N-acetyl derivative of 1, was achieved using coupling of 2-nitro-3-benzyloxyacetophenone 4 with the sodium salt of diethyl acetamidomalonate as a key step. This is the first reported synthesis of the lenticular glucopyranoside 2 and the N-acetyl compound 3.
