224052-17-9

Upstream product

• 197238-39-4 5-Nitro-2-(4-oxo-pentanoyloxymethyl)-benzoic acid 
• 50826-90-9 O^2'-tetrahydropyran-2-yl-uridine 
• 87-41-2 2-benzofuran-1(3H)-one 
• 612-20-4 2-(hydroxymethyl)benzoic acid 
• 189256-18-6 2-(4-Oxo-pentanoyloxymethyl)-benzoic acid 

Downstream Products

• 224052-20-4 5-Nitro-2-(4-oxo-pentanoyloxymethyl)-benzoic acid (2R,3R,4R,5R)-3-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester 

Relevant academic research and scientific papers

Oligonucleotide synthesis by the use of a 2-(levulinyloxymethyl)-5-nitrobenzoyl group as the novel base-labile protecting group for the 5'-hydroxyl groups of ribonucleoside and 2'-deoxyribonucleoside 3'-phosphoramidites

A novel 2-(levulinyloxymethyl)-5-nitrobenzoyl (LMNBz) protecting group for the 5' position of nucleoside 3'-phosphoramidites was successfully applied to the solid-phase synthesis of both an oligodeoxyribonucleotide (TpTpT and TpTpTpT) and an octaribonucleotide in combination with a 2'-O-Thp protecting group (UpCpApGpUpUpGpG). The LMNBz group was simply unmasked due to its base-labile property by a two-step procedure, i.e., treatments with 0.5 M hydrazine hydrate in 1:4 acetic acid - pyridine, and then with 0.5 M imidazole in acetonitrile.