22416-94-0

Usage

Uses

Used in Chemical Industry:
Propanimidoyl chloride, 3-chloro-N-hydroxy-2-oxois used as a chemical intermediate for the synthesis of various compounds. Its unique structure allows it to participate in a wide range of chemical reactions, making it a valuable asset in the development of new chemical products.
Used in Pharmaceutical Industry:
Propanimidoyl chloride, 3-chloro-N-hydroxy-2-oxois used as a key component in drug synthesis. Its reactivity and structural properties enable it to form essential bonds and connections with other molecules, contributing to the creation of new pharmaceutical compounds with potential therapeutic applications.
Used in Compound Manufacturing:
Propanimidoyl chloride, 3-chloro-N-hydroxy-2-oxois used as a building block in the production of complex organic compounds. Its versatility in forming chemical bonds allows it to be incorporated into the structures of various compounds, enhancing their properties and potential applications in different industries.

InChI:InChI=1/C3H3Cl2NO2/c4-1-2(7)3(5)6-8/h8H,1H2/b6-3-

Upstream product

• 5471-68-1 pyruvohydroximoyl chloride 
• 534-07-6 1,3-Dichloroacetone 
• 540-80-7 tert.-butylnitrite 
• 14337-41-8 1-chloro-3-(hydroxyimino)acetone 

Downstream Products

• 1446134-16-2 3-chloro-2-[3-(chloroacetyl)-4,5-dihydro-1,2-oxazol-5-yl]phenyl methanesulfonate 
• 1621190-76-8 methanesulfonic acid [1-{2-[3-(2-chloro-acetyl)-4,5-dihydro-isoxazol-5-yl]phenyl}ethylidene]hydrazide 
• 1253189-14-8 2-chloro-1-[5-(2,6-difluorophenyl)-4,5-dihydroisoxazol-3-yl]ethanone 
• 1173693-31-6 2-chloro-1-[4,5-dihydro-5-(2-fluorophenyl)-3-isoxazolyl]ethanone 
• 1173697-80-7 2-chloro-1-[4,5-dihydro-5-(3-iodophenyl)-3-isoxazolyl]ethanone 
• 1003320-09-9 2-chloro-1-(4,5-dihydro-5-phenyl-3-isoxazolyl)ethanone 

Relevant academic research and scientific papers

Estimation of dissociation constants (pK(a)'s) of oximes from proton chemical shifts in dimethyl sulfoxide solution

In connection with structure-activity studies of insecticidal methyl carbamoyloxime acetylcholinesterase inhibitors, a straightforward approach to estimating pK(a) values of a series of precursor oximes and thiohydroximates has been developed. The pK(a) values of oximes correlate well with the proton chemical shifts of the oximino proton (δ(OH)) in dilute dimethyl sulfoxide-d6 solution. The relationship pK(a) = 29.10 - 1.63δ(OH) was developed from δ(OH) and pK(a) data for 20 compounds available either from the literature or derived experimentally from half-neutralization potentials (ΔHNP). Using this relationship, pK(a) values of more than 200 hydroximino compounds were calculated. The relationship has been extended to also include phenols: pK(a) = 28.15 - 1.55δ(OH) - 3.96I(phenol), where I(phenol) is an indicator variable indicating application of the equation to either a phenol [I(phenol) = 1] or an oxime [I(phenol) = 0].

Compound containing indole ring structure, preparation method and application of compound, and bactericide

The invention belongs to the field of pesticides and discloses a compound containing an indole ring structure, a preparation method and application of the compound and a bactericide. The compound has the structure shown in the formula (I), and the compound has an excellent prevention and treatment effect on cucumber downy mildew, is equivalent to the current commercial oomycete disease prevention and treatment agent oxathiapiprolin, and has a good market development prospect.

Compound containing fused heterocyclic structure, preparation method and application of compound and bactericide

The invention relates to the field of pesticide bactericides, and discloses a compound containing a fused heterocyclic structure, a preparation method and application of the compound and a bactericide. The compound containing the fused heterocyclic structure has a structure as shown in a formula (1) or a formula (2). The compound has the excellent prevention and control effect on plant diseases caused by various oomycete pathogenic bacteria such as phytophthora infestans, phytophthora capsici, pythium ultinum, phytophthora nicotianae, peronophythora litchi and pseudoperonospora cubensis, is obviously superior to a conventional oomycete disease prevention and control agent, namely, dimethomorph, and has a very good market development prospect.

Compound containing fused heterocyclic structure, preparation method and application thereof and bactericide

The invention relates to the field of pesticide bactericides, and discloses a compound containing a fused heterocyclic structure, a preparation method and application thereof, and a bactericide. The compound containing the fused heterocyclic structure has a structure represented by formula (1). The compound provided by the invention has excellent prevention and treatment effects on plant diseasescaused by a plurality of oomycete pathogenic bacteria such as phytophthora infestans, phytophthora sojae, phytophthora capsici, peronophythora litchi and cucumber downy mildew, is obviously superior to the conventional oomycete disease prevention and treatment medicament dimethomorph, and has a good market development prospect.

Compound containing naphthenic pyrazole structure and preparation method and application thereof, and bactericide

The invention relates to the field of pesticide bactericides, and discloses a compound containing a naphthenic pyrazole structure and a preparation method and application thereof, and a bactericide. The compound containing the naphthenic pyrazole structure is a compound as shown in a formula (1) or agrochemically acceptable salts, hydrates and solvates thereof. The compound of the invention has excellent prevention and treatment effect on plant diseases caused by various oomycete pathogens such as Phytophthora infestans, Phytophthora capsici, Pythium ultimum, Phytophthora nicotianae, Peronophthora litchii and cucumber downy mildew, is obviously superior to the conventional oomycete disease control agent dimethomorph, and has a good market development prospect.

Discovery of oxathiapiprolin, a new oomycete fungicide that targets an oxysterol binding protein

Oxathiapiprolin is the first member of a new class of piperidinyl thiazole isoxazoline fungicides with exceptional activity against plant diseases caused by oomycete pathogens. It acts via inhibition of a novel fungal target - an oxysterol binding protein - resulting in excellent preventative, curative and residual efficacy against key diseases of grapes, potatoes and vegetables. Oxathiapiprolin is being developed globally as DuPont Zorvec disease control with first registration and sales anticipated in 2015. The discovery, synthesis, optimization and biological efficacy are presented.

PROCESS FOR PREPARING DIHYDROISOXAZOLE DERIVATIVES

The present invention relates to a novel process for preparing dihydroisoxazole derivatives.

MICROBIOCIDAL PYRAZOLE DERIVATIVES

Compounds of the formula (I) wherein the substituents are as defined in claim 1, are useful as a pesticides.

MICROBIOCIDAL PYRAZOLE DERIVATIVES

Compounds of the formula (I) wherein the substituents are as defined in claim 1, are useful as a pesticides.

AZOCYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE

Disclosed are compounds of Formula 1, including all stereoisomers, N oxides, and salts thereof, wherein A, W, X, G, R1, R2, R3, R4, m and n are as defined in the disclosure. Also disclosed are pharmaceutical compositions containing the compounds of Formula 1 and methods for treating a disease or condition mediated by fatty acid amide hydrolase activity comprising applying a therapeutically effective amount of a compound or a composition of the invention