224161-37-9

Basic information

• Product Name: 6-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
• Synonyms: 6-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE;Isoquinoline, 6-fluoro-1,2,3,4-tetrahydro- (9CI);Isoquinoline, 6-fluoro-1,2,3,4-tetrahydro-
• CAS NO: 224161-37-9
• Molecular Formula: C₉H₁₀FN
• Molecular Weight: 151.18
• Product Categories: HALIDE
• Mol File: 224161-37-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 227.55 °C at 760 mmHg
• Flash Point: 91.419 °C
• Appearance: /
• Density: 1.108 g/cm³
• CAS DataBase Reference: 6-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE(224161-37-9)
• EPA Substance Registry System: 6-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE(224161-37-9)

Safety Data

• Hazardous Substances Data: 224161-37-9(Hazardous Substances Data)

Usage

General Description

6-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE is a chemical compound with the molecular formula C9H10FNO. It is a fluorinated isoquinoline derivative, which is a type of organic compound that contains a six-membered benzene ring fused to a five-membered nitrogen-containing ring. 6-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE is commonly used as a building block in the synthesis of pharmaceuticals and other organic compounds. It has potential applications in drug development and medicinal chemistry due to its unique chemical structure and properties. Additionally, it may have biological activity and can be used as a research tool in the study of neurochemistry and pharmacology.

InChI:InChI=1/C9H10FN/c10-9-2-1-8-6-11-4-3-7(8)5-9/h1-2,5,11H,3-4,6H2

Upstream product

• 700-84-5 5-fluoro-1-indanone 
• 224161-38-0 6-fluoro-3,4-dihydroisoquinoline 
• 404-70-6 2-(3-Fluorophenyl)ethylamine 
• 214045-84-8 6-fluoro-3,4-dihydro-2H-isoquinolin-1-one 

Downstream Products

• 1009344-24-4 N-(2-chloro-4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-6-(trifluoromethyl)phenyl)-3,3-dimethylbutanamide 
• 1236265-32-9 N-ethyl-4-((4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-N-m-tolylbenzamide 
• 224161-38-0 6-fluoro-3,4-dihydroisoquinoline 

Relevant articles and documents

TRIAZOLOPHTHALAZINE COMPOUNDS, USE AS ANTI-HUMAN IMMUNODEFICIENCY VIRUS INHIBITORS OF HIV VIF-DEPENDENT DEGRADATION OF APOBEC3

The present disclosure is concerned with triazolophthalazine compounds that are capable of inhibiting infection by the Human Immunodeficiency Virus (HIV) by inhibiting HIV Vif-dependent degradation of the APOBEC3 innate immune system. The present disclosu

Metal-Free Synthesis of Polycyclic Quinazolinones Enabled by a (NH4)2S2O8-Promoted Intramolecular Oxidative Cyclization

An efficient metal-free, (NH4)2S2O8 mediated intramolecular oxidative cyclization for the construction of polycyclic heterocycles was disclosed. A series of polycyclic quinazolinone derivatives with good functional group tolerance were obtained in high yields. The natural products tryptanthrin and rutaecarpine, as well as their derivatives, were easily synthesized by this strategy. A preliminary mechanism study suggested the carbon-centered radical was involved in the catalytic cycle.

Synthesis and evaluation of tetrahydroisoquinoline-benzimidazole hybrids as multifunctional agents for the treatment of Alzheimer's disease

A novel series of tetrahydroisoquinoline-benzimidazole hybrids have been designed and synthesized as multifunctional agents against Alzheimer's disease (AD). These compounds were evaluated for their inhibition of neuroinflammation and human β-secretase (hBACE1), and neuroprotective activity. Among them, compound BD3 possessed significant anti-neuroinflammatory activity (IC50 = 5.07 μM against nitric oxide production) through inhibiting the expression and secretion of proinflammatory cytokines in BV2 cells. Compound BD3 also exhibited moderate hBACE1 inhibitory activity (65.7% inhibition at 20 μM) and potent neuroprotective effect by increasing GSH level and reducing ROS production (91.8% cell viability at 5 μM). Parallel artificial membrane permeation assay demonstrated that BD3 could cross the blood-brain barrier (BBB). Thus, this study demonstrates that the compounds with tetrahydroisoquinoline-benzimidazole scaffold are potential anti-AD agents, and they are worth for the further development.