224168-75-6Relevant academic research and scientific papers
NOVEL PHARMACEUTICALLY ACCEPTABLE SALTS OF 4-(1H-IMIDAZOL-4-YLMETHYL)PYRIDINE AND THEIR THERAPEUTICAL USES
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Page/Page column 13-14, (2010/12/18)
The present invention concerns novel pharmaceutical compositions of immethridine, in particular of novel pharmaceutically acceptable salts thereof, such as the dioxalate salt of immethridine, as well as its therapeutical uses and novel process of preparation.
Novel histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine scaffold
Vaccaro, Wayne D.,Sher, Rosy,Berlin, Michael,Shih, Neng-Yang,Aslanian, Robert,Schwerdt, John H.,McCormick, Kevin D.,Piwinski, John J.,West Jr., Robert E.,Anthes, John C.,Williams, Shirley M.,Wu, Ren-Long,She, H. Susan,Rivelli, Maria A.,Mutter, Jennifer C.,Corboz, Michel R.,Hey, John A.,Favreau, Leonard
, p. 395 - 399 (2007/10/03)
We report the discovery of novel histamine H3 receptor antagonists based on 4-[(1H-imidazol-4-yl)methyl]piperidine. The most potent compounds in the series (e.g., 7) result from the attachment of a substituted aniline amide to the main pharmaco
Synthesis and Structure-Activity Relationships of Conformationally Constrained Histamine H3 Receptor Agonists
Kitbunnadaj, Ruengwit,Zuiderveld, Obbe P.,De Esch, Iwan J. P.,Vollinga, Roeland C.,Bakker, Remko,Lutz, Martin,Spek, Anthony L.,Cavoy, Emile,Deltent, Marie-France,Menge, Wiro M. P. B.,Timmerman, Henk,Leurs, Rob
, p. 5445 - 5457 (2007/10/03)
Immepip, a conformationally constrained analogue of the histamine congener imbutamine, shows high affinity and functional activity on the human H 3 receptor. Using histamine and its homologues as prototypes, other rigid analogues containing eit
