224175-69-3Relevant academic research and scientific papers
Molecular design, synthesis and biological evaluation of 1,4-dihydro-4-oxoquinoline ribonucleosides as TcGAPDH inhibitors with trypanocidal activity
Soares, Fabyana A.,Sesti-Costa, Renata,Da Silva, Jo?o Santana,De Souza, Maria Cecília B.V.,Ferreira, Vitor F.,Da C. Santos, Fernanda,Monteiro, Patricia A.U.,Leit?o, Andrei,Montanari, Carlos A.
, p. 4597 - 4601 (2013/08/15)
The 1,4-dihydro-4-oxoquinoline ribonucleoside, Neq135, is the first low micromolar trypanosomatidae inhibitor to show good ligand efficiency (0.28 kcal mol-1 atom-1) and good ligand lipophilicity efficiency (0.37 kcal mol-1/sup
Synthesis and characterization of new porphyrin/4-quinolone conjugates
Gomes, Ana T.P.C.,Cunha, Anna C.,Domingues, Maria Do Rosário M.,Neves, Maria G.P.M.S.,Tomé, Augusto C.,Silva, Artur M.S.,Santos, Fernanda Da C.,Souza, Maria C.B.V.,Ferreira, Vitor F.,Cavaleiro, José A.S.
scheme or table, p. 7336 - 7342 (2011/10/09)
New porphyrin/4-quinolone conjugates were synthesized from the Suzuki-Miyaura coupling reaction of a β-borylated porphyrin with bromo-4-quinolones containing N-ethyl and N-d-ribofuranosyl substituents. The use of electrospray ionization tandem mass spectrometry showed important information about the fragmentation pathways of the new compounds. It was possible to distinguish between those compounds with the porphyrin moiety linked at the 6-position of the quinolone unit from their 7-substituted isomers. The new compounds showed to be good singlet oxygen generators.
