22422-19-1

Basic information

• Product Name: 3-chloro-1-(2,5-dimethylphenyl)propan-1-one
• CAS NO: 22422-19-1
• Molecular Formula: C₁₁H₁₃ClO
• Molecular Weight: 196.6733
• Mol File: 22422-19-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 303.9°C at 760 mmHg
• Flash Point: 162.1°C
• Density: 1.084g/cm³
• Vapor Pressure: 0.000901mmHg at 25°C
• Refractive Index: 1.522
• CAS DataBase Reference: 3-chloro-1-(2,5-dimethylphenyl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-1-(2,5-dimethylphenyl)propan-1-one(22422-19-1)
• EPA Substance Registry System: 3-chloro-1-(2,5-dimethylphenyl)propan-1-one(22422-19-1)

Safety Data

• Hazardous Substances Data: 22422-19-1(Hazardous Substances Data)

Upstream product

• 625-36-5 2-chloropropionyl chloride 
• 106-42-3 para-xylene 

Downstream Products

• 5037-60-5 4,7-dimethyl-indan-1-one 
• 610-72-0 2,5-dimethylbenzoic acid 
• 22422-20-4 3-chloro-1-(2,5-dimethylphenyl)-1-propanol 
• 108976-70-1 1-(2,5-dimethylphenyl)-3-phenylpropan-1-one 
• 6974-97-6 4,7-dimethyl-1H-indene 
• 84944-42-3 3,6-dimethylhomophthalic acid 
• 24623-36-7 4,7-dimethyl-2-(hydroxyimino)-1-indanone 
• 54889-59-7 4,8-dimethyl-3,5,6,7-tetrahydro-2H-s-indacen-1-one 
• 55836-31-2 4,8-dimethyl-1,2,3,5,6,7-hexahydrobenzo<1,2:4,5>dicyclopentene 
• 6682-71-9 4,7-dimethylindane 
• 49594-81-2 2,5-dimethyl-1-acryloylbenzene 

Relevant articles and documents

A combined computational and experimental investigation of the oxidative ring-opening of cyclic ethers by oxoammonium cations

The propensity of oxoammonium cations to facilitate the oxidative ring-opening of cyclic ethers to their corresponding distal hydroxy ketones is investigated. The reaction has been evaluated using experimental and computational methods to gain deeper insight into trends in reactivity.

Aromatic Spiranes XX [1]: Syntheses of Dimethylsubstituted 2-Carboxymethyl-indan-1-ones and Benzylchlorides as Synthones for Syntheses of di- to tetramethylsubstituted Spirobiindandiones

The isomeric dimethyl methylbenzoates 5, obtained from the bromides via Grignard reactions with dimethylcarbonate, were reduced with LiAlH4 to the hydroxymethyl derivatives 6. The latter were then transformed both to the benzylchlorides 7 (with SOCl2) and to the aldehydes 8 (with pyridinium chlorochromate). Knoevenagel-Doebner reaction of 8 afforded the acrylic acids 9 which (after hydrogenation to 11) were cyclized to the desired indanones 12 with polyphosphoric acid. On the other hand, 12c and 12e were prepared from dimethyl 3-chloropropiophenone (14) by warming with sulfuric acid. After NaH-catalyzed reaction with dimethylcarbonate, the indanones 12 gave the ketoesters 15 which then could be hydrogenated to the indanes 16. All reactions proceeded with satisfactory to excellent yields (60-90%).

Electron Paramagnetic Resonance Spectra of the Radical Cations of Some Benzocyclobutenes, Benzocyclopentenes and Benzocyclohexenes

1,2,4,5-Tetrahydrobenzodicyclobutene, 1,2,3,5,6,7-hexahydrobenzodicyclopentene and 1,2,3,4,6,7,8,9-octahydrobenzodicyclohexene, and their dimethyl derivatives, and tetramethylbenzocyclo-butene, -pentene and -hexene have been prepared.All except the first compound have been oxidised to their corresponding radical cations, and the EPR spectra have been analysed by assigning McConnell-type Q-values to the substituents in the benzene ring.It is suggested that the ordering of the orbital energy levels (ΨA above ΨS) in 3,6-dimethylbenzobiscyclobutene and -pentene is a manifestation of the Mills-Nixon effect, and results from rehybridisation of the strained molecular framework.In the radical cations of 5,10-dimethyl-1,2,3,4,6,7,8,9-octahydrobenzodicyclohexene and 5,6,7,8-tetramethyl-1,2,3,4-tetrahydrobenzocyclohexene the total unpaired electron density, as implied by the McConnell type of relationship, appears to be less than unity.Various possible causes of this are examined.