22422-27-1

Basic information

• Product Name: 3-chloro-1-(p-tolyl)propan-1-ol
• Synonyms: 3-chloro-1-(p-tolyl)propan-1-ol
• CAS NO: 22422-27-1
• Molecular Weight: 184.666
• Mol File: 22422-27-1.mol

Chemical Properties

• CAS DataBase Reference: 3-chloro-1-(p-tolyl)propan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-1-(p-tolyl)propan-1-ol(22422-27-1)
• EPA Substance Registry System: 3-chloro-1-(p-tolyl)propan-1-ol(22422-27-1)

Safety Data

• Hazardous Substances Data: 22422-27-1(Hazardous Substances Data)

Upstream product

• 108-88-3 toluene 
• 22422-21-5 4'-methyl-3-chloropropiophenone 

Downstream Products

• 1352742-03-0 (R)-3-chloro-1-p-tolylpropyl acetate 
• 1037716-92-9 1-(4-methylphenyl)-1-phenoxy-3-chloropropane 
• 1028270-76-9 1-(4-methylphenyl)-1-(2,4-dichlorophenoxy)-3-chloropropane 
• 1037717-03-5 1-(4-methylphenyl)-1-(2,4-dimethylphenoxy)-3-chloropropane 
• 1037716-93-0 1-(4-methylphenyl)-1-(4-chlorophenoxy)-3-chloropropane 
• 1037717-01-3 1-(4-methylphenyl)-1-(2-chloro-4-methylphenoxy)-3-chloropropane 
• 1037717-02-4 1-(4-methylphenyl)-1-(2-methyl-4-chlorophenoxy)-3-chloropropane 
• 1037717-00-2 1-(4-methylphenyl)-1-(3,5-dichlorophenoxy)-3-chloropropane 
• 1037716-98-5 1-(4-methylphenyl)-1-(4-tert-butylphenoxy)-3-chloropropane 
• 1037716-99-6 1-(4-methylphenyl)-1-(2,6-dichlorophenoxy)-3-chloropropane 
• 1037716-97-4 1-(4-methylphenyl)-1-(4-isopropylphenoxy)-3-chloropropane 
• 1037716-96-3 1-(4-methylphenyl)-1-(4-ethylphenoxy)-3-chloropropane 
• 1037716-95-2 1-(4-methylphenyl)-1-(4-methylphenoxy)-3-chloropropane 
• 820976-17-8 1-(1-bromo-3-chloro-propyl)-4-methyl-benzene 

Relevant articles and documents

Imidazole analogues of fluoxetine, a novel class of anti-Candida agents

Imidazole analogues of fluoxetine have been obtained by replacing the methylamino terminus of aminopropane chain with the imidazole ring. The newly designed imidazoles showed potent anti-Candida activity, superior to those of miconazole and other antifungal agents of clinical interest. 1-(4-Chlorophenyl)-l-(2,4-dichlorophenoxy)-3-(1H-imidazol-1-yl)propane (16), the most active among test imidazoles, Was about 2-fold more active and as much less cytotoxic than miconazole. High increase of activity was observed with methyl, nitro, fluorine, and chlorine (Cl > F > CH3 > NO2 > CF3).

1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies

New 1-[(3-aryloxy-3-aryl)propyl]-1H-imidazoles were synthesized and evaluated against Candida albicans and dermatophytes in order to develop structure-activity relationships (SARs). Against C. albicans the new imidazoles showed minimal inhibitory concentrations (MICs) comparable to those of ketoconazole, miconazole, and econazole, and were more potent than fluconazole. Several derivatives (10, 12, 14, 18-20, 24, 28, 29, 30, and 34) turned out to be potent inhibitors of C. albicans strains resistant to fluconazole, with MIC values less than 10 μg/mL. Against dermatophytes strains, compounds 20, 25, and 33 (MIC ≤ 5 μg/mL) were equipotent to ketoconazole, econazole, and miconazole. SARs of imidazoles 10-44 were rationalized with reasonable accuracy by a previously developed quantitative pharmacophore for antifungal agents.