22422-50-0Relevant academic research and scientific papers
Cyclocondensation of cyanoketene dithioacetal with 2-aminopyridine: Synthesis of pyrido [1, 2-a]pyrimidines
Singh, Okram Mukherjee,Ahmed, Mohd Farooque
, p. 1561 - 1564 (2007/10/03)
The cyanoketene dithioacetal 1 on treatment with 2-aminopyridine gives 2-ethoxy/2-methylthio/-3-cyano-4-oxo-4-H-pyrido [1, 2-al pyrimidines 2 and 3 in good yields. Compound 3 reacts with primary amines to afford 2-amino-3-cyano-4-oxo-4-H-pyrido [1, 2-a] pyrimidines 4a-d. 3 further reacts with hydrazine hydrate, hydroxylamine and guanidine nitrate to yield the corresponding tricyclic compounds 5, 6 and 7 in high yields.
