51531-96-5

Basic information

• Product Name: 2-(methylsulfanyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbonitrile
• Synonyms: 2-(methylsulfanyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbonitrile
• CAS NO: 51531-96-5
• Molecular Formula: C10H7N3OS
• Molecular Weight: 217.24708
• Mol File: 51531-96-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(methylsulfanyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(methylsulfanyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbonitrile(51531-96-5)
• EPA Substance Registry System: 2-(methylsulfanyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbonitrile(51531-96-5)

Safety Data

• Hazardous Substances Data: 51531-96-5(Hazardous Substances Data)

Upstream product

• 504-29-0 2-aminopyridine 
• 17823-58-4 ethyl 2-cyano-3,3-di(methylsulfanyl)acrylate 

Downstream Products

• 22422-50-0 2-benzylamino-3-cyano-4-oxo-4H-pyrido[1,2-a]pyrimidine 

Relevant articles and documents

Cyclocondensation of cyanoketene dithioacetal with 2-aminopyridine: Synthesis of pyrido [1, 2-a]pyrimidines

The cyanoketene dithioacetal 1 on treatment with 2-aminopyridine gives 2-ethoxy/2-methylthio/-3-cyano-4-oxo-4-H-pyrido [1, 2-al pyrimidines 2 and 3 in good yields. Compound 3 reacts with primary amines to afford 2-amino-3-cyano-4-oxo-4-H-pyrido [1, 2-a] pyrimidines 4a-d. 3 further reacts with hydrazine hydrate, hydroxylamine and guanidine nitrate to yield the corresponding tricyclic compounds 5, 6 and 7 in high yields.