51531-96-5Relevant academic research and scientific papers
Cyclocondensation of cyanoketene dithioacetal with 2-aminopyridine: Synthesis of pyrido [1, 2-a]pyrimidines
Singh, Okram Mukherjee,Ahmed, Mohd Farooque
, p. 1561 - 1564 (2007/10/03)
The cyanoketene dithioacetal 1 on treatment with 2-aminopyridine gives 2-ethoxy/2-methylthio/-3-cyano-4-oxo-4-H-pyrido [1, 2-al pyrimidines 2 and 3 in good yields. Compound 3 reacts with primary amines to afford 2-amino-3-cyano-4-oxo-4-H-pyrido [1, 2-a] pyrimidines 4a-d. 3 further reacts with hydrazine hydrate, hydroxylamine and guanidine nitrate to yield the corresponding tricyclic compounds 5, 6 and 7 in high yields.
Synthesis of pyridopyrimidone derivatives and their activity against P. falciparum in vitro
Dominguez,Charris,Iarrusso,Lopez,Lobo,Riggione
, p. 781 - 784 (2007/10/03)
Pyridopyrimidone derivatives 4a-d and 5a- were synthesized as potential antimalarial agents on the basis of the pharmacological properties of existing quinolone analogues such as ciprofloxacine IC50 39.8 μM. Meanwhile among these new compounds, only the 3-amino-7-methyl-1(H)pyrazolo[3,4-b]-pyrido[1,2:1'2']pyrimido-4-ona 4b, produces significant antimalarial activity IC50 0.42 μM against P. falciparum in vitro. The remaining compounds were effective as antimalarial agents leading from IC50 1.0 μM to IC50 4.47 μM.
