22428-85-9

Basic information

• Product Name: 4-Methylencyclohexanol
• Synonyms: 4-Methylencyclohexanol
• CAS NO: 22428-85-9
• Molecular Weight: 112.172
• Mol File: 22428-85-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 4-Methylencyclohexanol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methylencyclohexanol(22428-85-9)
• EPA Substance Registry System: 4-Methylencyclohexanol(22428-85-9)

Safety Data

• Hazardous Substances Data: 22428-85-9(Hazardous Substances Data)

Upstream product

• 51656-90-7 8-methylene-1,4-dioxaspiro[4.5]decane 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 13482-22-9 4-hydroxycyclohexanone 
• 2065-66-9 methyl-triphenylphosphonium iodide 
• 29648-66-6 4-methylenecyclohexanone 

Downstream Products

• 106434-94-0 1-Methoxy-4-methylencyclohexan 
• 1272667-39-6 ((1S,4S)-4-(5-(3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)methanol 
• 1272667-38-5 (1S,4S)-4-(5-(3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanecarbaldehyde 
• 1272667-53-4 ((1S,4S)-4-(5-(3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)methyl methanesulfonate 
• 1272667-52-3 5-(3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-7-((1s,4s)-4-(azidomethyl)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1272666-89-3 2-(3-((7-oxabicyclo[2.2.1]heptan-1-yl)methoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1272670-06-0 5-(3-(7-oxabtcyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-7-((1S,4S)-4-(aminomethyl)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1398924-07-6 d9-1-[4-fluoro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxymethyl]-7-oxa-bicyclo[2.2.1]heptane 
• 1398924-03-2 1-[4-fluoro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxymethyl]-7-oxa-bicyclo[2.2.1]heptane 
• 1398924-05-4 1-(3-bromo-4-fluoro-phenoxymethyl)-7-oxa-bicyclo[2.2.1]heptane 
• 1398923-91-5 1-[2-fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxymethyl]-7-oxa-bicyclo[2.2.1]heptane 
• 1398923-73-3 1-[2-fluoro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxymethyl]-7-oxa-bicyclo[2.2.1]heptane 
• 1398923-75-5 1-(3-bromo-2-fluoro-phenoxymethyl)-7-oxa-bicyclo[2.2.1]heptane 
• 29648-66-6 4-methylenecyclohexanone 

Relevant articles and documents

Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors

Taking the pyrrolopyrimidine derived IGF-1R inhibitor NVP-AEW541 as the starting point, the benzyl ether back-pocket binding moiety was replaced with a series of 2-cyclic ether methyl ethers leading to the identification of novel achiral [2.2.1]-bicyclic ether methyl ether containing analogues with improved IGF-1R activities and kinase selectivities. Further exploration of the series, including a fluorine scan of the 5-phenyl substituent, and optimisation of the sugar-pocket binding moiety identified compound 33 containing (S)-2-tetrahydrofuran methyl ether 6-fluorophenyl ether back-pocket, and cis-N-Ac-Pip sugar-pocket binding groups. Compound 33 showed improved selectivity and pharmacokinetics compared to NVP-AEW541, and produced comparable in vivo efficacy to linsitinib in inhibiting the growth of an IGF-1R dependent tumour xenograft model in the mouse.

HYDROXY SUBSTITUTED ISOQUINOLINONE DERIVATIVES

The invention relates to compounds of formula (I): as defined in the application. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.

Aminothiazole substituted penicillins and antibacterial compositions thereof

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt or in-vivo hydrolysable ester thereof: STR1 wherein R1 is hydrogen or an amino protecting group and R is substituted methyl; optionally substituted C2-12 alkyl, alkenyl or alkynyl; carbocyclyl; aryl or heterocyclyl. These compounds have antibacterial properties, and therefore are of use in the treatment of bacterial infections in humans and animals caused by a wide range of organisms.