224302-82-3Relevant academic research and scientific papers
Biologically active oligodeoxyribonucleotides. Part 12:1 N2-methylation of 2'-deoxyguanosines enhances stability of parallel G-quadruplex and anti-HIV-1 activity
Koizumi, Makoto,Akahori, Keika,Ohmine, Toshinori,Tsutsumi, Shinya,Sone, Junko,Kosaka, Toshiyuki,Kaneko, Masakatsu,Kimura, Satoshi,Shimada, Kaoru
, p. 2213 - 2216 (2007/10/03)
2'-Deoxyguanosine residues of a 3',5'-end-modified hexadeoxyribonucleotide (R-95288) with anti-HIV-1 activity were substituted with N2-methyl-2'-deoxyguanosine (m2dG). These modified oligodeoxyribonucleotides (ODNs) showed a 2-fold higher activity than R-95288. Also, the CD spectra of these ODNs indicated that the m2dG modification stabilized the tertiary structure of the G-quadruplex. (C) 2000 Elsevier Science Ltd.
