224314-08-3

Basic information

• Product Name: 2-tert-butyl-1-(4-nitro-phenyl)-1,4,5,6-tetrahydro-pyrimidine
• Synonyms: 2-tert-butyl-1-(4-nitro-phenyl)-1,4,5,6-tetrahydro-pyrimidine
• CAS NO: 224314-08-3
• Molecular Weight: 261.324
• Mol File: 224314-08-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-tert-butyl-1-(4-nitro-phenyl)-1,4,5,6-tetrahydro-pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-tert-butyl-1-(4-nitro-phenyl)-1,4,5,6-tetrahydro-pyrimidine(224314-08-3)
• EPA Substance Registry System: 2-tert-butyl-1-(4-nitro-phenyl)-1,4,5,6-tetrahydro-pyrimidine(224314-08-3)

Safety Data

• Hazardous Substances Data: 224314-08-3(Hazardous Substances Data)

Upstream product

• 3282-30-2 pivaloyl chloride 
• 52289-06-2 N-(p-nitrophenyl)trimethylenediamine 
• 224313-98-8 N-(2,2-dimethyl)propionyl-N'-(p-nitrophenyl)trimethylenediamine 

Relevant articles and documents

Microwave-enhanced synthesis of cyclic amidines

We present a simple and efficient microwave based protocol for the synthesis of heterocyclic amidines by PPE promoted cyclodehydration of N-aryl-N′-acylalkylenediamines. The method is general for five- to eight-membered heterocycles and affords high yield

Synthesis and properties of 1-aryl-2-alkyl-1,4,5,6- tetrahydropyrimidines

A general method is described for the synthesis of 1-aryl-2-alkyl- 1,4,5,6-tetrahydropyrimidines 1, by cyclization of N-acyl-N'- aryltrimethylenediamines 2 with trimethylsilyl polyphosphate. Precursors 2 were obtained by aminolysis of the corresponding N-(3-bromopropyl)arnides 3. The 1H nmr spectra of tetrahydropyrimidines 1 are analyzed, discussing the influence of substituents in positions 1 and 2 of the heterocyclic ring. Alkaline hydrolysis of compounds 1, which originates exclusively N-acyl-N'- aryltrimethylenediamines 2, through an intermediate carbinolamine, was also studied. Cleavage of such an intermediate is discussed in the light of the stereoelectronic control theory. Reduction of compounds 1 with borane, leads regiospecifically to N-alkyl-N'-aryltrimethylenediamines 6.