224315-46-2Relevant academic research and scientific papers
Synthesis of 2,3-disubstituted indoles by radical cyclization with hypophosphorous acid and its application to total synthesis of (±)-catharanthine
Reding, Matthew T.,Kaburagi, Yosuke,Tokuyama, Hidetoshi,Fukuyama, Tohru
, p. 313 - 330 (2007/10/03)
Radical cyclization of o-alkenylthioanilides using hypophosphorous acid and AIBN in the presence of Et3N proceeded smoothly to furnish the corresponding 2,3-disubstituted indoles in high yields. Utilizing the newly developed cyciization condition, a stereocontrolled total synthesis of (±)-catharanthine has been completed.
