224315-54-2

Upstream product

• 615-43-0 2-iodophenylamine 
• 78592-82-2 4-(tert-butyldimethylsilyloxy)-1-butyne 

Downstream Products

• 874796-29-9 1-[2-[(4-tert-butyldimethylsiloxy)-1-butynyl]phenyl]-3-(4-methoxyphenyl)urea 
• 1208105-20-7 C₁₉H₂₉NO₂Si 
• 874796-41-5 N-[2-[(4-tert-butyldimethylsiloxy)-1-butynyl]phenyl]-N'-(4-methoxyphenyl)carbodiimide 
• 224315-56-4 2-[4-(tert-butyl-dimethyl-silanyloxy)-but-1-enyl]-phenylamine 

Relevant academic research and scientific papers

Regioselective Synthesis of Substituted Carbazoles, Bicarbazoles, and Clausine C

Substituted carbazoles are efficiently constructed from 3-triflato-2-pyrones and alkynyl anilines. Multiple substituents are tolerated on the carbazole, and complete control of regiochemistry is observed. Complicated and sterically congested substitution patterns are produced. This strategy is also used to prepare substituted bicarbazoles and related biaryls. Finally, the method was showcased in a synthesis of the carbazole natural product clausine C.

Sequential Pd0- and PdII-Catalyzed Cyclizations: Enantioselective Heck and Nucleopalladation Reactions

An enantioselective consecutive cyclization/coupling process, catalyzed by palladium is reported. Stereoinduction arises from an enantioselective carbopalladation, generating an intermediate which promotes a nucleopalladation step. The dual cyclization se

Domino process in silver-catalyzed reactions of N-arylformimidates and active methylene compounds involving cycloisomerization and 1,3-alkenyl shift

(Formula Presented) We have developed an efficient method for the synthesis of 2,3-disubstituted indoles from alkyne iminoethers 1 that employs a domino process involving Ag-catalyzed condensation followed by a tandem Ag-induced cycloisomerization and 1,3

INDOLE DERIVATIVES AS HISTAMINE 3 RECEPTOR INHIBITORS FOR THE TREATMENT OF COGNITIVE AND SLEEP DISORDERS, OBESITY AND OTHER CNS DISORDERS

This invention relates to compounds having pharmacological activity, to compositions containing these compounds, and to a method of treatment employing the compounds and compositions. More particularly, this invention concerns certain indole derivatives and their salts and solvates. These compounds have H3 histamine receptor antagonist activity. This invention also relates to pharmaceutical compositions containing these compounds and to a method of treating disorders in which histamine H3 receptor blockade is beneficial.