22436-62-0Relevant academic research and scientific papers
Enantioselective synthesis of cis-α-substituted cycloalkanols and trans-cycloalkyl amines thereof
Fernández, Rosario,Ros, Abel,Magriz, Antonio,Dietrich, Hansj?rg,Lassaletta, José M.
, p. 6755 - 6763 (2007)
The diastereo- and enantioselective syntheses of trans-cycloalkyl amines was accomplished through a three-step sequence consisting of: (1) asymmetric transfer hydrogenation through dynamic kinetic resolution of bicyclic and monocyclic α-substituted ketones using HCO2H/Et3N as the hydrogen source and TsDPEN-based Ru(II) catalysts, (2) nucleophilic hydroxyl to azide substitution of the resulting cis-cycloalkanols using diphenyl phosphoryl azide under modified Mitsunobu conditions, and (3) reduction of the trans-azide intermediates with LiAlH4 of PPh3/H2O to the desired targets.
PHASE TRANSFER CATALYSIS AND HOMOGENEOUS REACTIONS WITH β-OXYALKYL RADICALS FROM ORGANOMERCURIALS
Barluenga, Jose,Lopez-Prado, Joaquin,Campos, Pedro J.,Asensio, Gregorio
, p. 2863 - 2868 (2007/10/02)
β-Alkoxy- and β-hydroxyalkyl radicals generated by sodium borohydride reduction of oxymercurials react with electron deficient olefins to give addition compounds in a homogeneous process.Heterogeneous reactions are also successful in the presence of catalytic amounts of surfactants and provide a superior method for the "one pot" reductive alkylation of oxymercurials.
