224449-33-6

Usage

Uses

Used in Pharmaceutical Industry:
4-Bromo-3-thiophenecarboxylic acid ethyl ester is used as a synthetic intermediate for the development of various pharmaceutical compounds. Its unique structure and reactivity allow for the creation of a wide range of therapeutic agents, including those with potential applications in the treatment of various diseases and conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Bromo-3-thiophenecarboxylic acid ethyl ester serves as a key intermediate in the synthesis of pesticides and other crop protection agents. Its ability to participate in various chemical reactions enables the production of effective and targeted agrochemicals that can protect crops from pests and diseases.
Used in Organic Synthesis:
4-Bromo-3-thiophenecarboxylic acid ethyl ester is utilized as a versatile building block in organic synthesis. Its capacity to undergo esterification and bromination reactions makes it a valuable starting material for the production of a diverse array of organic compounds, including those with potential applications in various industries.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 4-Bromo-3-thiophenecarboxylic acid ethyl ester is employed as a reagent for the synthesis of complex molecular structures with potential therapeutic properties. Its unique chemical properties and reactivity contribute to the development of innovative drug candidates and the advancement of medicinal chemistry research.

Upstream product

• 3141-26-2 3,4-dibromothiophene 
• 1068-55-9 isopropylmagnesium chloride 
• 541-41-3 chloroformic acid ethyl ester 

Downstream Products

• 1002761-80-9 N-tert-butyl ester-N-(4-benzylsulfanyl-5-nitro-thiophen-3-ylmethyl)-methanesulfonamide 
• 1002761-79-6 3-benzylsulfanyl-4-chloromethyl-2-nitro-thiophene 
• 1002761-78-5 4-benzylsulfanyl-5-nitro-thiophene-3-carboxylic acid ethyl ester 
• 686271-29-4 (4-benzylsulfanyl-5-nitro-thiophen-3-yl)-methanol 
• 57279-64-8 4-(2-oxo-2-phenylethyl)thiophene-3-carboxylic acid 
• 70438-00-5 4-ethoxy-thiophene-3-carboxylic acid 
• 57279-53-5 6-phenyl-5H-thieno[3,4-c]pyridin-4-one 
• 16694-17-0 4-bromo-3-thiophenecarboxylic acid 

Relevant academic research and scientific papers

Synthesis of Tetrasubstituted Thiophenes via Direct Metalation

Thiophene moiety can be derivatized by various synthetic procedures. The most convenient method seems to be derivatization via direct metalation, but synthesis of polysubstituted thiophenes bearing reactive groups is difficult because of high reactivity of organometallic reagents. This work reports the preparation of complex heterocyclic compounds using direct metalation of thiophenes with various reagents (Knochel-Hauser bases, LDA) as an efficient synthetic tool.

Compound as potassium channel modulator

The invention relates to a compound as a potassium channel modulator, which is a compound of a formula (I) or a pharmaceutically acceptable salt thereof. The compound or the pharmaceutically acceptable salt thereof is effective for curing and preventing diseases and symptoms influenced by the activity of potassium ion channels.

PIPERIDINE ISOXAZOLE AND ISOTHIAZOLE OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to piperidine isoxazole and isothiazole orexin compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

6,5-BICYCLIC OCTAHYDROPYRROLOPYRIDINE OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to 6,5-bicyclic octahydropyrrolopyridine compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

PIPERIDINE OXADIAZOLE AND THIADIAZOLE OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to piperidine oxadiazole and thiadiazole orexin compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

ETHYLDIAMINE OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to ethyldiamne compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

FUSED HETEROARYL DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS

Fused heteroaryl derivative compounds which are antagonists of orexin receptors are provided. The compounds can be used in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. Also provided is a composition which comprises the compound can be use to prevent or treat such diseases in which orexin receptors are involved.

AMIDOETHYL AZOLE OREXIN RECEPTOR ANTAGONISTS

An amidoethyl azole compounds are provided as antagonists of orexin receptors. The compounds may be used for treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved.

PYRROLIDINE OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to pyrrolidine compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

THIAZOLE OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to thiazole compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the thiazole compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.