224451-10-9Relevant academic research and scientific papers
Synthesis and antimalarial activity of 11 dispiro-1,2,4,5-tetraoxane analogues of WR 148999. 7,8,15,16-tetraoxadispiro[5.2.5.2]hexadecanes substituted at the 1 and 10 positions with unsaturated and polar functional groups
Dong, Yuxiang,Matile, Hugues,Chollet, Jacques,Kaminsky, Ronald,Wood, James K.,Vennerstrom, Jonathan L.
, p. 1477 - 1480 (1999)
Eleven novel dispiro-1,2,4,5-tetraoxanes 3 bearing unsaturated and polar functional groups were designed to enhance the oral antimalarial activity of the prototype tetraoxane 2 (WR 148999). With the exception of 3g and 3h, tetraoxanes 3 were available via
