224456-19-3Relevant academic research and scientific papers
Synthesis of new 2,5-disubstituted-1,3,4-thiadiazoles and preliminary evaluation of anticonvulsant and antimicrobial activities
Dogan, Hatice N,Duran, Arzu,Rollas, Sevim,Sener, G?ksel,Uysal, Meral K,Gülen, Dumrul
, p. 2893 - 2898 (2002)
Two new series of 2,5-disubstituted-1,3,4-thiadiazoles were synthesized for their possible anticonvulsant, antibacterial and antifungal activities. The degree of protection afforded by these compounds at a dose of 100 mg/kg ip against pentylenetetrazole-induced convulsions in mice ranged from 0 to 90%. Among these compounds, 2a (90%) and 2g (70%) showed maximum protection. Antimicrobial tests showed that the MIC value of 3j against Pseudomanas aeruginosa was equal to that of penicillin.
Synthesis and preliminary anticancer activity of new 1,4-dihydro-3-(3-hydroxy-2-naphthyl)-4-substituted-5H-1,2,4-triazoline-5- thiones
Duran,Dogan,Rollas, Sevim
, p. 559 - 564 (2002)
1,4-Dihydro-3-(3-hydroxy-2-naphthyl)-4-substituted-5H-L2,4-triazolinc-5- thiones were synthesized. The structures of original eight compounds were confirmed by elemental analysis,1H NMR and mass spectral methods. One of the compounds (3a) was t
