224580-04-5

Upstream product

• 224580-03-4 tert-Butyl-[(2S,3R)-3-(4-methoxy-benzyloxy)-2,3,7-trimethyl-oct-6-enyloxy]-dimethyl-silane 
• 224580-02-3 (4R,5S)-2-(4-Methoxy-phenyl)-4,5-dimethyl-4-(4-methyl-pent-3-enyl)-[1,3]dioxane 
• 2186-92-7 p-Anisaldehyde dimethyl acetal 
• 224579-92-4 (2S,3R)-3-(4-Methoxy-benzyloxy)-2,3,7-trimethyl-oct-6-en-1-ol 

Downstream Products

• 224579-93-5 tert-Butyl-[(2S,3R)-3-(4-methoxy-benzyloxy)-2,3-dimethyl-hex-5-enyloxy]-dimethyl-silane 
• 224580-05-6 tert-Butyl-[(2S,3R)-3-(4-methoxy-benzyloxy)-2,3-dimethyl-4-(S)-oxiranyl-butoxy]-dimethyl-silane 
• 224580-07-8 (2S,3R,5S,8R,9S,10R,12S)-1,5,8,9-Tetrakis-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,3,10-trimethyl-12-triisopropylsilanyloxy-tridecan-7-one 
• 224580-01-2 (2S,3R,5S,8R,9S,10R,12S)-5,8,9-Tris-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-3-(4-methoxy-benzyloxy)-2,3,10-trimethyl-12-triisopropylsilanyloxy-tridecan-7-one 
• 224580-00-1 (2S,3R,5S,8R,9S,10R,12S)-1,5-Bis-(tert-butyl-dimethyl-silanyloxy)-8,9-dihydroxy-3-(4-methoxy-benzyloxy)-2,3,10-trimethyl-12-triisopropylsilanyloxy-tridecan-7-one 
• 224579-99-1 (E)-(2S,4R,9S,11R,12S)-9,13-Bis-(tert-butyl-dimethyl-silanyloxy)-11-(4-methoxy-benzyloxy)-4,11,12-trimethyl-2-triisopropylsilanyloxy-tridec-5-en-7-one 
• 224579-97-9 [(4S,6R,7S)-4,8-Bis-(tert-butyl-dimethyl-silanyloxy)-6-(4-methoxy-benzyloxy)-6,7-dimethyl-2-oxo-octyl]-phosphonic acid dimethyl ester 
• 224580-06-7 (3R,5R,6S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-5,6-dimethyl-heptanenitrile 
• 224579-96-8 (3S,5R,6S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-5,6-dimethyl-heptanal 
• 224579-94-6 (2S,4R,5S)-6-(tert-Butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-4,5-dimethyl-hexane-1,2-diol 
• 224579-95-7 (3R,5R,6S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-5-(4-methoxy-benzyloxy)-5,6-dimethyl-heptanenitrile 

Relevant academic research and scientific papers

β-nitro-α-amino acids as latent α,β-dehydro-α-amino acid residues in peptides

Peptides containing α,β-dehydro-α-amino acid residues are readily prepared by incorporating β-nitro-α-amino acids at the corresponding positions, followed by elimination of nitrous acid.

2. Synthesis of the C.14-C.26 hydrophilic domain of amphidinolide B1 and formation of the (E)-1,1',3-trisubstituted diene sector

In the preceding letter, we described a synthesis of the conserved C.1- C.13 hydrophobic domain common to the potent B-type amphidinolides. In this letter, we present syntheses of the C.14-C.26 hydrophilic domain specific to amphidinolide B1 and a model for uniting the hydrophobic and hydrophilic domains to form the (E)-1,1',3-trisubstituted diene.