224580-02-3

Upstream product

• 50727-94-1 (2R,3R)-3-methyl-3-(4-methyl-3-pentenyl)oxiranemethanol 
• 2186-92-7 p-Anisaldehyde dimethyl acetal 
• 224579-91-3 (2S,3R)-2,3,7-Trimethyl-oct-6-ene-1,3-diol 

Downstream Products

• 224580-07-8 (2S,3R,5S,8R,9S,10R,12S)-1,5,8,9-Tetrakis-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,3,10-trimethyl-12-triisopropylsilanyloxy-tridecan-7-one 
• 224580-01-2 (2S,3R,5S,8R,9S,10R,12S)-5,8,9-Tris-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-3-(4-methoxy-benzyloxy)-2,3,10-trimethyl-12-triisopropylsilanyloxy-tridecan-7-one 
• 224580-00-1 (2S,3R,5S,8R,9S,10R,12S)-1,5-Bis-(tert-butyl-dimethyl-silanyloxy)-8,9-dihydroxy-3-(4-methoxy-benzyloxy)-2,3,10-trimethyl-12-triisopropylsilanyloxy-tridecan-7-one 
• 224579-99-1 (E)-(2S,4R,9S,11R,12S)-9,13-Bis-(tert-butyl-dimethyl-silanyloxy)-11-(4-methoxy-benzyloxy)-4,11,12-trimethyl-2-triisopropylsilanyloxy-tridec-5-en-7-one 
• 224579-97-9 [(4S,6R,7S)-4,8-Bis-(tert-butyl-dimethyl-silanyloxy)-6-(4-methoxy-benzyloxy)-6,7-dimethyl-2-oxo-octyl]-phosphonic acid dimethyl ester 
• 224580-09-0 Trifluoro-acetic acid (2S,3R)-3-(4-methoxy-benzyloxy)-2,3,7-trimethyl-1-(1-methylene-heptyl)-oct-6-enyl ester 
• 224580-06-7 (3R,5R,6S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-5,6-dimethyl-heptanenitrile 
• 224579-96-8 (3S,5R,6S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-5,6-dimethyl-heptanal 
• 224580-08-9 (6R,7S)-6-(4-Methoxy-benzyloxy)-2,6,7-trimethyl-9-methylene-pentadec-2-en-8-ol 
• 224579-94-6 (2S,4R,5S)-6-(tert-Butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-4,5-dimethyl-hexane-1,2-diol 
• 224579-95-7 (3R,5R,6S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-5-(4-methoxy-benzyloxy)-5,6-dimethyl-heptanenitrile 
• 224580-04-5 (4R,5S)-6-(tert-Butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-4,5-dimethyl-hexan-1-ol 
• 224580-03-4 tert-Butyl-[(2S,3R)-3-(4-methoxy-benzyloxy)-2,3,7-trimethyl-oct-6-enyloxy]-dimethyl-silane 
• 224580-05-6 tert-Butyl-[(2S,3R)-3-(4-methoxy-benzyloxy)-2,3-dimethyl-4-(S)-oxiranyl-butoxy]-dimethyl-silane 

Relevant academic research and scientific papers

2. Synthesis of the C.14-C.26 hydrophilic domain of amphidinolide B1 and formation of the (E)-1,1',3-trisubstituted diene sector

In the preceding letter, we described a synthesis of the conserved C.1- C.13 hydrophobic domain common to the potent B-type amphidinolides. In this letter, we present syntheses of the C.14-C.26 hydrophilic domain specific to amphidinolide B1 and a model for uniting the hydrophobic and hydrophilic domains to form the (E)-1,1',3-trisubstituted diene.